Crystal structure of ATAD2A bromodomain complexed with H4(1-20)K5Ac peptide

Summary for 4TT2

Related4TT4 4TT6 4TTE 4TU4 4TU6
DescriptorATPase family AAA domain-containing protein 2, Histone H4K5Ac (3 entities in total)
Functional Keywordsbromodomain-acetylated histone complex, gene regulation
Biological sourceHomo sapiens (Human)
Cellular locationNucleus  Q6PL18
Total number of polymer chains2
Total molecular weight16057.17
Poncet-Montange, G.,Zhan, Y.,Bardenhagen, J.,Petrocchi, A.,Leo, E.,Shi, X.,Lee, G.,Leonard, P.,Geck Do, M.,Cardozo, M.,Palmer, W.,Andersen, J.,Jones, P.,Ladbury, J. (deposition date: 2014-06-19, release date: 2014-12-24, Last modification date: 2017-11-22)
Primary citation
Poncet-Montange, G.,Zhan, Y.,Bardenhagen, J.P.,Petrocchi, A.,Leo, E.,Shi, X.,Lee, G.R.,Leonard, P.G.,Geck Do, M.K.,Cardozo, M.G.,Andersen, J.N.,Palmer, W.S.,Jones, P.,Ladbury, J.E.
Observed bromodomain flexibility reveals histone peptide- and small molecule ligand-compatible forms of ATAD2.
Biochem.J., 466:337-346, 2015
PubMed: 25486442 (PDB entries with the same primary citation)
DOI: 10.1042/BJ20140933
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.261200.8%1.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution