5FH6
Crystal structure of the fifth bromodomain of human PB1 in complex with compound 10
Summary for 5FH6
Entry DOI | 10.2210/pdb5fh6/pdb |
Descriptor | Protein polybromo-1, (3~{R})-3-(piperidin-1-ylmethyl)-2,3-dihydro-1~{H}-pyrrolo[1,2-a]quinazolin-5-one (3 entities in total) |
Functional Keywords | pbrm1, brg1-associated factor 180, transcription, chromatin remodeling |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: Q86U86 |
Total number of polymer chains | 4 |
Total formula weight | 59725.47 |
Authors | Tallant, C.,Sutherell, C.L.,Siejka, P.,Krojer, T.,Picaud, S.,Fonseca, M.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Brennan, P.E.,Ley, S.V.,Knapp, S. (deposition date: 2015-12-21, release date: 2016-06-01, Last modification date: 2024-01-10) |
Primary citation | Sutherell, C.L.,Tallant, C.,Monteiro, O.P.,Yapp, C.,Fuchs, J.E.,Fedorov, O.,Siejka, P.,Muller, S.,Knapp, S.,Brenton, J.D.,Brennan, P.E.,Ley, S.V. Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex. J.Med.Chem., 59:5095-5101, 2016 Cited by PubMed: 27119626DOI: 10.1021/acs.jmedchem.5b01997 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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