5FH6
Crystal structure of the fifth bromodomain of human PB1 in complex with compound 10
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0016586 | cellular_component | RSC-type complex |
| B | 0006338 | biological_process | chromatin remodeling |
| B | 0016586 | cellular_component | RSC-type complex |
| C | 0006338 | biological_process | chromatin remodeling |
| C | 0016586 | cellular_component | RSC-type complex |
| D | 0006338 | biological_process | chromatin remodeling |
| D | 0016586 | cellular_component | RSC-type complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue 5XM A 801 |
| Chain | Residue |
| A | ILE683 |
| A | PHE684 |
| A | LEU687 |
| A | TYR696 |
| A | MET704 |
| A | ALA735 |
| A | ASN739 |
| A | ILE745 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue 5XM B 801 |
| Chain | Residue |
| B | PHE684 |
| B | LEU687 |
| B | TYR696 |
| B | MET704 |
| B | ASP705 |
| B | ALA735 |
| B | TYR738 |
| C | 5XM801 |
| B | ILE683 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue 5XM C 801 |
| Chain | Residue |
| B | 5XM801 |
| C | ILE683 |
| C | PHE684 |
| C | LEU687 |
| C | TYR696 |
| C | ALA735 |
| C | ASN739 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue 5XM D 801 |
| Chain | Residue |
| D | ILE683 |
| D | ARG686 |
| D | LEU687 |
| D | PRO688 |
| D | TYR696 |
| D | MET704 |
| D | ALA735 |
| D | ASN739 |
| D | ILE745 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 58 |
| Details | BROMODOMAIN_1 Bromodomain signature. SaiFlrlpSrselp..DYYltIkkpMdmekIrshmmank..Yqdidsmvedfvm.MfnNActY |
| Chain | Residue | Details |
| A | SER681-TYR738 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 220 |
| Details | Domain: {"description":"Bromo 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00035","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
