4RVR

Crystal Structure of the bromodomain of human BAZ2B in complex WITH GSK2801

Summary for 4RVR

Entry DOI	10.2210/pdb4rvr/pdb
Related	4IR3 4IR4 4IR5 4IR6
Descriptor	Bromodomain adjacent to zinc finger domain protein 2B, 1-{1-[2-(methylsulfonyl)phenyl]-7-propoxyindolizin-3-yl}ethanone, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	sgc, structural genomics consortium, transcription, acetylated lysine binding protein, kiaa1476, walp4, chemical probe
Biological source	Homo sapiens (human)
Cellular location	Nucleus : Q9UIF8
Total number of polymer chains	1
Total formula weight	14362.51
Authors	Chaikuad, A.,Felletar, I.,Chung, C.W.,Drewry, D.,Chen, P.,Filippakopoulos, P.,Fedorov, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2014-11-27, release date: 2014-12-10, Last modification date: 2023-09-20)
Primary citation	Chen, P.,Chaikuad, A.,Bamborough, P.,Bantscheff, M.,Bountra, C.,Chung, C.W.,Fedorov, O.,Grandi, P.,Jung, D.,Lesniak, R.,Lindon, M.,Muller, S.,Philpott, M.,Prinjha, R.,Rogers, C.,Selenski, C.,Tallant, C.,Werner, T.,Willson, T.M.,Knapp, S.,Drewry, D.H. Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B. J.Med.Chem., 59:1410-1424, 2016 Cited by PubMed: 25799074 DOI: 10.1021/acs.jmedchem.5b00209 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.98 Å)

Structure validation