4TYL

Fragment-Based Screening of the Bromodomain of ATAD2

Summary for 4TYL

Related4TZ2 4TZ8
DescriptorATPase family AAA domain-containing protein 2, SULFATE ION, CHLORIDE ION, ... (5 entities in total)
Functional Keywordsbromodomain, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationNucleus  Q6PL18
Total number of polymer chains1
Total molecular weight15882.62
Authors
Harner, M.J.,Chauder, B.A.,Phan, J.,Fesik, S.W. (deposition date: 2014-07-08, release date: 2014-10-29, Last modification date: 2017-09-06)
Primary citation
Harner, M.J.,Chauder, B.A.,Phan, J.,Fesik, S.W.
Fragment-Based Screening of the Bromodomain of ATAD2.
J.Med.Chem., 57:9687-9692, 2014
PubMed: 25314628 (PDB entries with the same primary citation)
DOI: 10.1021/jm501035j
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.85 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.199601.7%0MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution