PDB: 278 件ウェブページステータス検索Chemie searchBIRD

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6NHK	Mortalin nucleotide binding domain in the ADP-bound state 分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... 著者 Page, R.C, Moseng, M.A, Nix, J.C. 登録日 2018-12-23 公開日 2019-04-17 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.777 Å) 主引用文献 Biophysical Consequences of EVEN-PLUS Syndrome Mutations for the Function of Mortalin. J.Phys.Chem.B, 123, 2019
6GFA	Structure of Nucleotide binding domain of HSP110, ATP and Mg2+ complexed 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein 105 kDa, MAGNESIUM ION 著者 Gonzalez, D, Gotthard, G, Gozzi, G.J, Seigneuric, R, Neiers, F, Briand, L, Garrido, C. 登録日 2018-04-29 公開日 2019-05-08 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Selecting the first chemical molecule inhibitor of HSP110 for colorectal cancer therapy. Cell Death Differ., 27, 2020
6DFO	Crystal structure of human GRP78 in complex with 8-bromoadenosine 分子名称: 8-bromoadenosine, Endoplasmic reticulum chaperone BiP 著者 Ferrie, R.P, Chen, Y, Antoshchenko, T, Cooney, O.M, Huang, Y, Park, H.W. 登録日 2018-05-15 公開日 2019-05-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.54 Å) 主引用文献 Crystal structure of human GRP78 in complex with 8-bromoadenosine To be Published
6DFM	Crystal structure of human GRP78 in complex with 8-aminoadenosine 分子名称: (2R,3R,4S,5R)-2-(6,8-diaminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol, Endoplasmic reticulum chaperone BiP 著者 Ferrie, R.P, Chen, Y, Antoshchenko, T, Cooney, O.M, Huang, Y, Park, H.W. 登録日 2018-05-15 公開日 2019-05-15 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Crystal structure of human GRP78 in complex with 8-aminoadenosine To be Published
6DO2	Crystal structure of human GRP78 in complex with 7-deaza-2'-C-methyladenosine 分子名称: 7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Endoplasmic reticulum chaperone BiP 著者 Ferrie, R.P, Chen, Y, Antoshchenko, T, Cooney, O.M, Huang, Y, Park, H.W. 登録日 2018-06-08 公開日 2019-06-12 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of human GRP78 in complex with 7-deaza-2'-C-methyladenosine To Be Published
6P2U	Structure of Mortalin-NBD with N6-propargyladenosine-5'-diphosphate 分子名称: 9-{5-O-[(S)-hydroxy(phosphonooxy)phosphoryl]-alpha-D-ribofuranosyl}-N-(prop-2-yn-1-yl)-9H-purin-6-amine, MAGNESIUM ION, PHOSPHATE ION, ... 著者 Moseng, M.A, Page, R.C. 登録日 2019-05-22 公開日 2019-06-19 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 2- and N6-functionalized adenosine-5'-diphosphate analogs for the inhibition of mortalin. Febs Lett., 593, 2019
6DWS	Crystal structure of human GRP78 in complex with (2R,3R,4S,5R)-2-(6-amino-8-((2-chlorobenzyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol 分子名称: 8-{[(2-chlorophenyl)methyl]amino}adenosine, Endoplasmic reticulum chaperone BiP, MAGNESIUM ION 著者 Chen, Y, Antoshchenko, T, Smil, D, Zepeda, C, Huang, Y, Park, H.W. 登録日 2018-06-27 公開日 2019-07-03 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of human GRP78 in complex with (2R,3R,4S,5R)-2-(6-amino-8-((2-chlorobenzyl)amino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol To Be Published
6H54	CRYSTAL STRUCTURE OF BOVINE HSC70(AA1-554)E213A/D214A IN COMPLEX WITH INHIBITOR VER155008 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile, GLYCEROL, ... 著者 Plank, C, Zehe, M, Grimm, C, Sotriffer, C. 登録日 2018-07-23 公開日 2019-08-14 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct. Acs Chem.Biol., 2024
6RZQ	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain - ANP-PnP bound state 分子名称: GLYCEROL, Heat shock protein 70, MAGNESIUM ION, ... 著者 Vakonakis, I, Day, J. 登録日 2019-06-13 公開日 2019-10-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 ThePlasmodium falciparumHsp70-x chaperone assists the heat stress response of the malaria parasite. Faseb J., 33, 2019
6S02	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain - ADP bound state 分子名称: ADENOSINE-5'-DIPHOSPHATE, Heat shock protein 70, MAGNESIUM ION 著者 Vakonakis, I, Day, J. 登録日 2019-06-13 公開日 2019-10-02 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 ThePlasmodium falciparumHsp70-x chaperone assists the heat stress response of the malaria parasite. Faseb J., 33, 2019
6U42	Natively decorated ciliary doublet microtubule 分子名称: DC1, DC2, DC3, ... 著者 Ma, M, Stoyanova, M, Rademacher, G, Dutcher, S.K, Brown, A, Zhang, R. 登録日 2019-08-22 公開日 2019-11-13 最終更新日 2020-01-08 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structure of the Decorated Ciliary Doublet Microtubule. Cell, 179, 2019
6SR6	Crystal structure of the RAC core with a pseudo substrate bound to Ssz1 SBD 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Putative heat shock protein, ... 著者 Valentin Gese, G, Lapouge, K, Kopp, J, Sinning, I. 登録日 2019-09-05 公開日 2020-03-25 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The ribosome-associated complex RAC serves in a relay that directs nascent chains to Ssb. Nat Commun, 11, 2020
6PMT	Structure of Mortalin-NBD with adenosine-5'-monophosphate and thiodiphosphate 分子名称: ADENOSINE MONOPHOSPHATE, PHOSPHATE ION, Stress-70 protein, ... 著者 Moseng, M.A, Nix, J.C, Page, R.C. 登録日 2019-07-02 公開日 2020-07-08 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of the mortalin nucleotide binding domain in complex with adenosine monophosphate to be published
7JNE	Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide RGSQLRIASR 分子名称: Alkaline phosphatase peptide, Chaperone protein DnaK, SULFATE ION 著者 Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C. 登録日 2020-08-04 公開日 2020-08-26 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.54 Å) 主引用文献 Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein. Proc.Natl.Acad.Sci.USA, 118, 2021
7JN9	Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide QEHTGSQLRIAAYGP 分子名称: Alkaline phosphatase peptide, Chaperone protein DnaK, SULFATE ION 著者 Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C. 登録日 2020-08-04 公開日 2020-08-26 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein. Proc.Natl.Acad.Sci.USA, 118, 2021
7JMM	Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide RAKNIILLSR 分子名称: Alkaline phosphatase, Chaperone protein DnaK, SULFATE ION 著者 Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C. 登録日 2020-08-02 公開日 2020-08-26 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.56 Å) 主引用文献 Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein. Proc.Natl.Acad.Sci.USA, 118, 2021
7JN8	Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide RGNTLVIVSR 分子名称: Alkaline phosphatase peptide, Chaperone protein DnaK, SULFATE ION 著者 Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C. 登録日 2020-08-04 公開日 2020-08-26 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (3.09 Å) 主引用文献 Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein. Proc.Natl.Acad.Sci.USA, 118, 2021
6ZHI	Structure of the Plasmodium falciparum Hsp70-x substrate binding domain in complex with hydrophobic peptide 分子名称: ASN-ARG-LEU-LEU-LEU-THR-GLY, Heat shock protein 70 著者 Schmidt, J, Vakonakis, I. 登録日 2020-06-23 公開日 2020-09-09 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Structure of the PfHsp70-x SBD Acta Crystallographica Section F
6ZYI	Crystal structure of HSP70 ATPase domain in complex with ADP and calcium 分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Heat shock 70kDa protein 1A variant 著者 Yan, Y, Preissler, S, Ron, D. 登録日 2020-08-01 公開日 2020-12-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.52 Å) 主引用文献 Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes. Elife, 9, 2020
6ZYJ	Crystal structure of Hsc70 ATPase domain in complex with ADP and calcium 分子名称: ACETATE ION, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... 著者 Yan, Y, Preissler, S, Ron, D. 登録日 2020-08-01 公開日 2020-12-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes. Elife, 9, 2020
7A4V	Crystal structure of lid-truncated ADP-bound BiP in an oligomeric state 分子名称: ADENOSINE-5'-DIPHOSPHATE, Endoplasmic reticulum chaperone BiP, GLYCEROL, ... 著者 Perera, L.A, Ron, D. 登録日 2020-08-20 公開日 2020-12-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes. Elife, 9, 2020
6ZYH	Crystal structure of GRP78 (70kDa heat shock protein 5 / BiP) ATPase domain in complex with ADP and calcium 分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Endoplasmic reticulum chaperone BiP 著者 Yan, Y, Preissler, S, Ron, D. 登録日 2020-08-01 公開日 2020-12-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes. Elife, 9, 2020
7A4U	Crystal structure of lid-truncated apo BiP in an oligomeric state 分子名称: Endoplasmic reticulum chaperone BiP, GLYCEROL 著者 Perera, L.A, Ron, D. 登録日 2020-08-20 公開日 2020-12-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.77 Å) 主引用文献 Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes. Elife, 9, 2020
7NQZ	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with Z1827898537 分子名称: (3S)-N-benzylpyrrolidin-3-amine, AMP PHOSPHORAMIDATE, CHLORIDE ION, ... 著者 Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I. 登録日 2021-03-02 公開日 2021-03-10 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.319 Å) 主引用文献 Structures of P. falciparum Hsp70-x nucleotide binding domain with small molecule ligands To Be Published
7NQR	Plasmodium falciparum Hsp70-x chaperone nucleotide binding domain in complex with Z287256168 分子名称: (S)-N-(1-cyclopropylethyl)-6-methylpicolinamide, 1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE, AMP PHOSPHORAMIDATE, ... 著者 Mohamad, N, O'Donoghue, A, Kantsadi, A.L, Vakonakis, I. 登録日 2021-03-02 公開日 2021-03-10 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Structures of P. falciparum Hsp70-x nucleotide binding domain with small molecule ligands To Be Published

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