6DO2

Crystal structure of human GRP78 in complex with 7-deaza-2'-C-methyladenosine

Summary for 6DO2

DescriptorEndoplasmic reticulum chaperone BiP, 7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (3 entities in total)
Functional Keywordshuman grp78, adenosine analog, chaperone, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight84871.99
Authors
Ferrie, R.P.,Chen, Y.,Antoshchenko, T.,Cooney, O.M.,Huang, Y.,Park, H.W. (deposition date: 2018-06-08, release date: 2019-06-12)
Primary citation
Ferrie, R.P.,Chen, Y.,Antoshchenko, T.,Cooney, O.M.,Huang, Y.,Park, H.W.
Crystal structure of human GRP78 in complex with 7-deaza-2'-C-methyladenosine
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.7 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23820 0.8% 9.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution