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6H54

CRYSTAL STRUCTURE OF BOVINE HSC70(AA1-554)E213A/D214A IN COMPLEX WITH INHIBITOR VER155008

Summary for 6H54
Entry DOI10.2210/pdb6h54/pdb
Related4fl9
DescriptorHeat shock cognate 71 kDa protein, trimethylamine oxide, 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile, ... (6 entities in total)
Functional Keywordschaperone, hsc70, vernalis inhibitor
Biological sourceBos taurus (cattle)
Total number of polymer chains1
Total formula weight61940.78
Authors
Plank, C.,Zehe, M.,Grimm, C.,Sotriffer, C. (deposition date: 2018-07-23, release date: 2019-08-14, Last modification date: 2024-02-14)
Primary citationZehe, M.,Kehrein, J.,Schollmayer, C.,Plank, C.,Kovacs, H.,Merino Asumendi, E.,Holzgrabe, U.,Grimm, C.,Sotriffer, C.
Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct.
Acs Chem.Biol., 2024
Cited by
PubMed: 38317495
DOI: 10.1021/acschembio.3c00589
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.02 Å)
Structure validation

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