PDB: 250 件ウェブページステータス検索Chemie searchBIRD

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5WAK	Crystal Structure of a Suz12-Rbbp4 Binary Complex 分子名称: Histone-binding protein RBBP4, Polycomb protein SUZ12, ZINC ION 著者 Chen, S, Jiao, L, Liu, X. 登録日 2017-06-26 公開日 2018-03-14 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding. Mol. Cell, 69, 2018
2XAS	Crystal structure of LSD1-CoREST in complex with a tranylcypromine derivative (MC2580, 14e) 分子名称: 3-[4-({N-[(BENZYLOXY)CARBONYL]-L-PHENYLALANYL}AMINO)PHENYL]PROPANOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ... 著者 Binda, C, Valente, S, Romanenghi, M, Pilotto, S, Cirilli, R, Karytinos, A, Ciossani, G, Botrugno, O.A, Forneris, F, Tardugno, M, Edmondson, D.E, Minucci, S, Mattevi, A, Mai, A. 登録日 2010-03-31 公開日 2010-05-05 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2. J.Am.Chem.Soc., 132, 2010
5ZNR	Crystal structure of PtSHL in complex with an H3K27me3 peptide 分子名称: 17-mer peptide from Histone H3.2, SHORT LIFE family protein, SULFATE ION, ... 著者 Lv, X, Du, J. 登録日 2018-04-10 公開日 2018-07-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.202 Å) 主引用文献 Dual recognition of H3K4me3 and H3K27me3 by a plant histone reader SHL. Nat Commun, 9, 2018
2XAF	Crystal structure of LSD1-CoREST in complex with para-bromo-(+)-cis-2- phenylcyclopropyl-1-amine 分子名称: 3-(4-BROMOPHENYL)PROPANAMIDE, FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ... 著者 Binda, C, Valente, S, Romanenghi, M, Pilotto, S, Cirilli, R, Karytinos, A, Ciossani, G, Botrugno, O.A, Forneris, F, Tardugno, M, Edmondson, D.E, Minucci, S, Mattevi, A, Mai, A. 登録日 2010-03-31 公開日 2010-05-05 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.25 Å) 主引用文献 Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2. J.Am.Chem.Soc., 132, 2010
5Y5W	Crystal structure of human Spindlin1 in complex with a histone H4K20(me3) peptide 分子名称: Histone peptide H4K20(me3), Spindlin-1 著者 Wang, C, Zang, J. 登録日 2017-08-10 公開日 2017-10-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Spindlin-1 recognizes methylations of K20 and R23 of histone H4 tail FEBS Lett., 592, 2018
5L3B	Human LSD1/CoREST: LSD1 D556G mutation 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1A, REST corepressor 1 著者 Pilotto, S, Speranzini, V, Marabelli, C. 登録日 2016-04-06 公開日 2016-05-04 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 LSD1/KDM1A mutations associated to a newly described form of intellectual disability impair demethylase activity and binding to transcription factors. Hum.Mol.Genet., 25, 2016
8F8Z	PHF2 (PHD+JMJ) in Complex with H3 Histone N-Terminal Peptide 分子名称: 1,2-ETHANEDIOL, H3 N-Terminal Peptide, Lysine-specific demethylase PHF2, ... 著者 Horton, J.R, Cheng, X. 登録日 2022-11-22 公開日 2023-01-18 最終更新日 2023-02-08 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2. J.Biol.Chem., 299, 2022
2XAJ	Crystal structure of LSD1-CoREST in complex with (-)-trans-2- phenylcyclopropyl-1-amine 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, PHENYLETHYLENECARBOXYLIC ACID, ... 著者 Binda, C, Valente, S, Romanenghi, M, Pilotto, S, Cirilli, R, Karytinos, A, Ciossani, G, Botrugno, O.A, Forneris, F, Tardugno, M, Edmondson, D.E, Minucci, S, Mattevi, A, Mai, A. 登録日 2010-03-31 公開日 2010-05-05 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2. J.Am.Chem.Soc., 132, 2010
5L3C	Human LSD1/CoREST: LSD1 E379K mutation 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, Lysine-specific histone demethylase 1A, REST corepressor 1 著者 Pilotto, S, Speranzini, V, Marabelli, C, Mattevi, A. 登録日 2016-04-06 公開日 2016-05-04 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.31 Å) 主引用文献 LSD1/KDM1A mutations associated to a newly described form of intellectual disability impair demethylase activity and binding to transcription factors. Hum.Mol.Genet., 25, 2016
5LHG	Structure of the KDM1A/CoREST complex with the inhibitor 4-methyl-N-[4-[[4-(1-methylpiperidin-4-yl)oxyphenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide 分子名称: 4-methyl-N-[4-[[4-[(1-methyl-4-piperidyl)oxy]phenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... 著者 Cecatiello, V, Pasqualato, S. 登録日 2016-07-11 公開日 2017-02-22 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.34 Å) 主引用文献 Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship. J. Med. Chem., 60, 2017
8FYH	G4 RNA-mediated PRC2 dimer 分子名称: G4 RNA, Histone-binding protein RBBP4, Histone-lysine N-methyltransferase EZH2, ... 著者 Song, J, Kasinath, V. 登録日 2023-01-26 公開日 2023-10-04 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural basis for inactivation of PRC2 by G-quadruplex RNA. Science, 381, 2023
5LHI	Structure of the KDM1A/CoREST complex with the inhibitor N-[3-(ethoxymethyl)-2-[[4-[[(3R)-pyrrolidin-3-yl]methoxy]phenoxy]methyl]phenyl]-4-methylthieno[3,2-b]pyrrole-5-carboxamide 分子名称: FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, ... 著者 Cecatiello, V, Pasqualato, S. 登録日 2016-07-12 公開日 2017-02-22 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship. J. Med. Chem., 60, 2017
6WKR	PRC2-AEBP2-JARID2 bound to H2AK119ub1 nucleosome 分子名称: DNA (314-MER), Histone H2A type 1, Histone H2B 1.1, ... 著者 Kasinath, V, Nogales, E, Beck, C, Sauer, P, Poepsel, S, Kosmatka, J, Faini, M, Toso, D, Aebersold, R. 登録日 2020-04-16 公開日 2021-02-03 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications. Science, 371, 2021
7BU9	Crystal Structure of Spindlin1-H3(K4me3-K9me2) complex 分子名称: H3(K4me3-K9me2) peptide, Spindlin-1 著者 Zhao, F, Li, H. 登録日 2020-04-05 公開日 2020-10-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (3.502 Å) 主引用文献 Molecular basis for histone H3 "K4me3-K9me3/2" methylation pattern readout by Spindlin1. J.Biol.Chem., 295, 2020
3MWY	Crystal structure of the chromodomain-ATPase portion of the yeast Chd1 chromatin remodeler 分子名称: Chromo domain-containing protein 1, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER 著者 Hauk, G, Bowman, G.D. 登録日 2010-05-06 公開日 2010-09-29 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 The chromodomains of the Chd1 chromatin remodeler regulate DNA access to the ATPase motor. Mol.Cell, 39, 2010
4U7P	Crystal structure of DNMT3A-DNMT3L complex 分子名称: DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3A, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Wang, L, Guo, X, Li, J, Xiao, J, Yin, X, He, S, Wang, J, Xu, Y. 登録日 2014-07-31 公開日 2014-11-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (3.821 Å) 主引用文献 Structural insight into autoinhibition and histone H3-induced activation of DNMT3A Nature, 517, 2015
6R1U	Structure of LSD2/NPAC-linker/nucleosome core particle complex: Class 2 分子名称: DNA (147-MER), FLAVIN-ADENINE DINUCLEOTIDE, Histone H2A, ... 著者 Marabelli, C, Pilotto, S, Chittori, S, Subramaniam, S, Mattevi, A. 登録日 2019-03-15 公開日 2019-04-24 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (4.36 Å) 主引用文献 A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex. Cell Rep, 27, 2019
6W5M	Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class02) 分子名称: DNA (147-MER), Histone H2A type 1, Histone H2B 1.1, ... 著者 Park, S.H, Lee, Y.T, Ayoub, A, Dou, Y, Cho, U. 登録日 2020-03-13 公開日 2021-03-31 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. Nat Commun, 12, 2021
6R25	Structure of LSD2/NPAC-linker/nucleosome core particle complex: Class 3 分子名称: DNA (147-MER), FLAVIN-ADENINE DINUCLEOTIDE, H2B, ... 著者 Marabelli, C, Pilotto, S, Chittori, S, Subramaniam, S, Mattevi, A. 登録日 2019-03-15 公開日 2019-04-24 実験手法 ELECTRON MICROSCOPY (4.61 Å) 主引用文献 A Tail-Based Mechanism Drives Nucleosome Demethylation by the LSD2/NPAC Multimeric Complex. Cell Rep, 27, 2019
6W5N	Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class05) 分子名称: DNA (147-MER), Histone H2A type 1, Histone H2B 1.1, ... 著者 Park, S.H, Lee, Y.T, Ayoub, A, Dou, Y, Cho, U. 登録日 2020-03-13 公開日 2021-03-31 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (6 Å) 主引用文献 Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. Nat Commun, 12, 2021
6W5I	Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class01) 分子名称: DNA (147-MER), Histone H2A, Histone H2B 1.1, ... 著者 Park, S.H, Lee, Y.T, Ayoub, A, Dou, Y, Cho, U. 登録日 2020-03-13 公開日 2021-03-31 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (6.9 Å) 主引用文献 Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. Nat Commun, 12, 2021
1WE9	Solution structure of PHD domain in nucleic acid binding protein-like NP_197993 分子名称: PHD finger family protein, ZINC ION 著者 He, F, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2004-05-24 公開日 2004-11-24 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of PHD domain in nucleic acid binding protein-like NP_197993 To be Published
7ZEY	Complex Cyp33-RRM : MLL1-PHD3 分子名称: MLL cleavage product N320, Peptidyl-prolyl cis-trans isomerase E, ZINC ION 著者 Blatter, M, Allain, F, Meylan, C. 登録日 2022-03-31 公開日 2022-04-13 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription. Sci Adv, 9, 2023
1WES	Solution structure of PHD domain in inhibitor of growth family, member 1-like 分子名称: ZINC ION, inhibitor of growth family, member 1-like 著者 He, F, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2004-05-25 公開日 2004-11-25 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of PHD domain in inhibitor of growth family, member 1-like To be Published
2FUI	NMR solution structure of PHD finger fragment of human BPTF in free state 分子名称: bromodomain PHD finger transcription factor 著者 Ilin, S, Patel, D.J. 登録日 2006-01-26 公開日 2006-07-11 最終更新日 2022-03-09 実験手法 SOLUTION NMR 主引用文献 Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF. Nature, 442, 2006

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