2XAS
Crystal structure of LSD1-CoREST in complex with a tranylcypromine derivative (MC2580, 14e)
Summary for 2XAS
Entry DOI | 10.2210/pdb2xas/pdb |
Related | 2COM 2H94 2IW5 2UXN 2UXX 2V1D 2X0L 2XAF 2XAG 2XAH 2XAJ 2XAQ |
Descriptor | LYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ... (4 entities in total) |
Functional Keywords | amine oxidase, chromatin regulator, histone inhibitor binding, methylation, nucleosome core, oxidoreductase, oxidoreductase-repressor complex, chromatin remodelling, transcription |
Biological source | HOMO SAPIENS More |
Cellular location | Nucleus: O60341 Q9UKL0 |
Total number of polymer chains | 2 |
Total formula weight | 147345.46 |
Authors | Binda, C.,Valente, S.,Romanenghi, M.,Pilotto, S.,Cirilli, R.,Karytinos, A.,Ciossani, G.,Botrugno, O.A.,Forneris, F.,Tardugno, M.,Edmondson, D.E.,Minucci, S.,Mattevi, A.,Mai, A. (deposition date: 2010-03-31, release date: 2010-05-05, Last modification date: 2024-05-08) |
Primary citation | Binda, C.,Valente, S.,Romanenghi, M.,Pilotto, S.,Cirilli, R.,Karytinos, A.,Ciossani, G.,Botrugno, O.A.,Forneris, F.,Tardugno, M.,Edmondson, D.E.,Minucci, S.,Mattevi, A.,Mai, A. Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2. J.Am.Chem.Soc., 132:6827-, 2010 Cited by PubMed: 20415477DOI: 10.1021/JA101557K PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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