6W5I
Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class01)
Summary for 6W5I
Entry DOI | 10.2210/pdb6w5i/pdb |
EMDB information | 21542 21544 |
Descriptor | Retinoblastoma-binding protein 5, DNA (147-MER), WD repeat-containing protein 5, ... (10 entities in total) |
Functional Keywords | mll1-ncp, h3k4 methylation, transferase, transferase-structural protein-dna complex, transferase/structural protein/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 14 |
Total formula weight | 377915.14 |
Authors | Park, S.H.,Lee, Y.T.,Ayoub, A.,Dou, Y.,Cho, U. (deposition date: 2020-03-13, release date: 2021-03-31, Last modification date: 2024-05-29) |
Primary citation | Lee, Y.T.,Ayoub, A.,Park, S.H.,Sha, L.,Xu, J.,Mao, F.,Zheng, W.,Zhang, Y.,Cho, U.S.,Dou, Y. Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. Nat Commun, 12:2953-2953, 2021 Cited by PubMed: 34012049DOI: 10.1038/s41467-021-23268-9 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (6.9 Å) |
Structure validation
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