5L3C

Human LSD1/CoREST: LSD1 E379K mutation

Summary for 5L3C

DescriptorLysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE (3 entities in total)
Functional Keywordsoxidoreductase-repressor complex, histone demethylase, chromatin, flavin, fad, oxidoreductase/repressor
Biological sourceHomo sapiens (Human)
Cellular locationNucleus  O60341 Q9UKL0
Total number of polymer chains2
Total molecular weight146899.03
Authors
Pilotto, S.,Speranzini, V.,Marabelli, C.,Mattevi, A. (deposition date: 2016-04-06, release date: 2016-05-04, Last modification date: 2016-12-07)
Primary citation
Pilotto, S.,Speranzini, V.,Marabelli, C.,Rusconi, F.,Toffolo, E.,Grillo, B.,Battaglioli, E.,Mattevi, A.
LSD1/KDM1A mutations associated to a newly described form of intellectual disability impair demethylase activity and binding to transcription factors.
Hum.Mol.Genet., 25:2578-2587, 2016
PubMed: 27094131 (PDB entries with the same primary citation)
DOI: 10.1093/hmg/ddw120
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.31 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22830.3%6.0%0.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report