PDB: 187313 件ウェブページステータス検索Chemie searchBIRD

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2FMO	Ala177Val mutant of E. coli Methylenetetrahydrofolate Reductase 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 5,10-methylenetetrahydrofolate reductase, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Pejchal, R, Campbell, E, Guenther, B.D, Lennon, B.W, Matthews, R.G, Ludwig, M.L. 登録日 2006-01-09 公開日 2006-04-25 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural Perturbations in the Ala -> Val Polymorphism of Methylenetetrahydrofolate Reductase: How Binding of Folates May Protect against Inactivation Biochemistry, 45, 2006
1QCZ	CRYSTAL STRUCTURE OF E. COLI PURE, AN UNUSUAL MUTASE THAT CATALYZES THE CONVERSION OF N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE (N5-CAIR) TO 4-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE (CAIR) IN THE PURINE BIOSYNTHETIC PATHWAY 分子名称: N5-CARBOXYAMINOIMIDAZOLE RIBONUCLEOTIDE MUTASE 著者 Ealick, S.E, Mathews, I.I. 登録日 1999-05-10 公開日 1999-11-10 最終更新日 2024-10-30 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Crystal structure of Escherichia coli PurE, an unusual mutase in the purine biosynthetic pathway. Structure Fold.Des., 7, 1999
2CJU	Crystal structure of the TEPC15-Vk45.1 anti-2-phenyl-5-oxazolone NQ16- 113.8 scFv in complex with phOxGABA 分子名称: 4-{[(Z)-(5-OXO-2-PHENYL-1,3-OXAZOL-4(5H)-YLIDENE)METHYL]AMINO}BUTANOIC ACID, NQ16-113.8 ANTI-PHOX ANTIBODY 著者 Scotti, C, Gherardi, E. 登録日 2006-04-09 公開日 2006-06-20 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural Basis of Affinity Maturation of the Tepc15/V(Kappa)45.1 Anti-2-Phenyl-5-Oxazolone Antibodies. J.Mol.Biol., 359, 2006
4RAO	Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their pro-drugs as antimalarial agents 分子名称: (2-{[2-(6-oxo-1,6-dihydro-9H-purin-9-yl)ethyl](2-{[(E)-2-phosphonoethenyl]oxy}ethyl)amino}ethyl)phosphonic acid, Hypoxanthine-guanine phosphoribosyltransferase, MAGNESIUM ION 著者 Keough, D.T, Hockova, D, Janeba, Z, Wang, T.-H, Naesens, L, Edstein, M.D, Chavchich, M, Guddat, L.W. 登録日 2014-09-10 公開日 2015-01-07 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.871 Å) 主引用文献 Aza-acyclic Nucleoside Phosphonates Containing a Second Phosphonate Group As Inhibitors of the Human, Plasmodium falciparum and vivax 6-Oxopurine Phosphoribosyltransferases and Their Prodrugs As Antimalarial Agents. J.Med.Chem., 58, 2015
3JZI	Crystal structure of biotin carboxylase from E. Coli in complex with benzimidazole series 分子名称: 7-amino-2-[(2-chlorobenzyl)amino]-1-{[(1S,2S)-2-hydroxycycloheptyl]methyl}-1H-benzimidazole-5-carboxamide, Biotin carboxylase 著者 Cheng, C, Shipps, G.W, Yang, Z, Sun, B, Kawahata, N, Soucy, K, Soriano, A, Orth, P, Xiao, L, Mann, P, Black, T. 登録日 2009-09-23 公開日 2009-11-03 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 Discovery and optimization of antibacterial AccC inhibitors. Bioorg.Med.Chem.Lett., 19, 2009
4EHM	RabGGTase in complex with covalently bound Psoromic acid 分子名称: 4-formyl-3-hydroxy-8-methoxy-1,9-dimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepine-6-carboxylic acid, CALCIUM ION, Geranylgeranyl transferase type-2 subunit alpha, ... 著者 Guo, Z, Deraeve, C, Bon, R.S, Alexandrov, K, Waldmann, H, Wu, Y.W, Goody, R.S, Blankenfeldt, W. 登録日 2012-04-02 公開日 2012-05-30 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Psoromic Acid is a Selective and Covalent Rab-Prenylation Inhibitor Targeting Autoinhibited RabGGTase J.Am.Chem.Soc., 134, 2012
4CEW	Crystal structure of human Enterovirus 71 in complex with the uncoating inhibitor ALD 分子名称: 4-[3-[(3s)-5-[4-[(e)-ethoxyiminomethyl]phenoxy]-3-methyl-pentyl]-2-oxidanylidene-imidazolidin-1-yl]pyridine-2-carboxamide, VP1, VP2, ... 著者 De Colibus, L, Wang, X, Spyrou, J.A.B, Kelly, J, Ren, J, Grimes, J, Puerstinger, G, Stonehouse, N, Walter, T.S, Hu, Z, Wang, J, Li, X, Peng, W, Rowlands, D, Fry, E.E, Rao, Z, Stuart, D.I. 登録日 2013-11-12 公開日 2014-02-12 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 More-Powerful Virus Inhibitors from Structure-Based Analysis of Hev71 Capsid-Binding Molecules. Nat.Struct.Mol.Biol., 21, 2014
4CDU	Crystal structure of human Enterovirus 71 in complex with the uncoating inhibitor GPP3 分子名称: 1-[(3S)-5-[4-[(E)-ETHOXYIMINOMETHYL]PHENOXY]-3-METHYL-PENTYL]-3-PYRIDIN-4-YL-IMIDAZOLIDIN-2-ONE, CHLORIDE ION, SODIUM ION, ... 著者 De Colibus, L, Wang, X, Spyrou, J.A.B, Kelly, J, Ren, J, Grimes, J, Puerstinger, G, Stonehouse, N, Walter, T.S, Hu, Z, Wang, J, Li, X, Peng, W, Rowlands, D, Fry, E.E, Rao, Z, Stuart, D.I. 登録日 2013-11-06 公開日 2014-02-12 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 More-Powerful Virus Inhibitors from Structure-Based Analysis of Hev71 Capsid-Binding Molecules Nat.Struct.Mol.Biol., 21, 2014
2UUD	Crystal structure of the TEPC15-Vk45.1 anti-2-phenyl-5-oxazolone NQ10- 1.12 scFv in complex with the hapten 分子名称: 4-{[(Z)-(5-OXO-2-PHENYL-1,3-OXAZOL-4(5H)-YLIDENE)METHYL]AMINO}BUTANOIC ACID, NQ10-1.12 ANTI-PHOX ANTIBODY 著者 Scotti, C, Gherardi, E. 登録日 2007-03-02 公開日 2007-04-03 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Structural Basis of Affinity Maturation of the Tepc15-Vkappa45.1 Anti-2-Phenyl-5-Oxazolone Antibodies J.Mol.Biol., 359, 2006
3RV8	Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Cyclopropyl R-Group 分子名称: 3-{[(E)-1-carboxy-2-cyclopropylethenyl]oxy}-2-hydroxybenzoic acid, 3-{[(Z)-1-carboxy-2-cyclopropylethenyl]oxy}-2-hydroxybenzoic acid, Isochorismate synthase/isochorismate-pyruvate lyase mbtI 著者 Chi, G, Bulloch, E.M.M, Manos-Turvey, A, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC) 登録日 2011-05-06 公開日 2012-05-09 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.29 Å) 主引用文献 Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis Biochemistry, 51, 2012
3RV6	Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Phenyl R-Group 分子名称: 3-{[(E)-1-carboxy-2-phenylethenyl]oxy}-2-hydroxybenzoic acid, 3-{[(Z)-1-carboxy-2-phenylethenyl]oxy}-2-hydroxybenzoic acid, Isochorismate synthase/isochorismate-pyruvate lyase mbtI, ... 著者 Chi, G, Bulloch, E.M.M, Manos-Turvey, A, Payne, R.J, Lott, J.S, TB Structural Genomics Consortium (TBSGC) 登録日 2011-05-06 公開日 2012-05-09 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.04 Å) 主引用文献 Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis Biochemistry, 51, 2012
3S7H	Structure of thrombin mutant Y225P in the E* form 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Prothrombin 著者 Niu, W, Chen, Z, Gandhi, P, Vogt, A, Pozzi, N, Pele, L.A, Zapata, F, Di Cera, E. 登録日 2011-05-26 公開日 2011-07-06 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystallographic and Kinetic Evidence of Allostery in a Trypsin-like Protease. Biochemistry, 50, 2011
4HTQ	Mitigation of X-ray damage in macromolecular crystallography by submicrometer line focusing; total dose 6.70 x 10e+11 X-ray photons 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Lysozyme C, ... 著者 Duke, N.E.C, Finfrock, Y.Z, Stern, E.Z, Alkire, R.W, Lazarski, K, Joachimiak, A. 登録日 2012-11-01 公開日 2013-05-15 最終更新日 2024-11-27 実験手法 X-RAY DIFFRACTION (1.399 Å) 主引用文献 Mitigation of X-ray damage in macromolecular crystallography by submicrometre line focusing. Acta Crystallogr.,Sect.D, 69, 2013
3KXW	The crystal structure of fatty acid AMP ligase from Legionella pneumophila 分子名称: 5'-O-[(S)-(dodecanoyloxy)(hydroxy)phosphoryl]adenosine, Saframycin Mx1 synthetase B 著者 Zhang, Z, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC) 登録日 2009-12-04 公開日 2010-03-16 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (1.851 Å) 主引用文献 Structural and Functional Studies of Fatty Acyl Adenylate Ligases from E. coli and L. pneumophila. J.Mol.Biol., 406, 2011
4E8B	Crystal structure of 16S rRNA Methyltransferase RsmE from E.coli 分子名称: Ribosomal RNA small subunit methyltransferase E 著者 Zhang, H, Gao, Z.Q, Dong, Y.H. 登録日 2012-03-20 公開日 2012-09-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.249 Å) 主引用文献 Insights into the catalytic mechanism of 16S rRNA methyltransferase RsmE (m(3)U1498) from crystal and solution structures J.Mol.Biol., 423, 2012
2OOL	Crystal structure of the chromophore-binding domain of an unusual bacteriophytochrome RpBphP3 from R. palustris 分子名称: 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3- yl]propanoic acid, Sensor protein 著者 Yang, X, Stojkovic, E.A, Kuk, J, Moffat, K. 登録日 2007-01-25 公開日 2007-07-10 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of the chromophore binding domain of an unusual bacteriophytochrome, RpBphP3, reveals residues that modulate photoconversion. Proc.Natl.Acad.Sci.Usa, 104, 2007
5JZQ	Ultrahigh-resolution centrosymmetric crystal structure of Z-DNA reveals massive presence of multiple conformations 分子名称: DNA (5'-D(*CP*GP*CP*GP*CP*G)-3'), MAGNESIUM ION 著者 Drozdzal, P, Gilski, M, Jaskolski, M. 登録日 2016-05-17 公開日 2016-11-09 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (0.78 Å) 主引用文献 Ultrahigh-resolution centrosymmetric crystal structure of Z-DNA reveals the massive presence of alternate conformations. Acta Crystallogr D Struct Biol, 72, 2016
4Q0J	Deinococcus radiodurans BphP photosensory module 分子名称: 3-[2-[(Z)-[3-(2-carboxyethyl)-5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-pyrrol-1-ium -2-ylidene]methyl]-5-[(Z)-[(3E)-3-ethylidene-4-methyl-5-oxidanylidene-pyrrolidin-2-ylidene]methyl]-4-methyl-1H-pyrrol-3- yl]propanoic acid, Bacteriophytochrome 著者 Burgie, E.S, Vierstra, R.D. 登録日 2014-04-02 公開日 2014-07-16 最終更新日 2024-11-27 実験手法 X-RAY DIFFRACTION (2.747 Å) 主引用文献 Crystallographic and Electron Microscopic Analyses of a Bacterial Phytochrome Reveal Local and Global Rearrangements during Photoconversion. J.Biol.Chem., 289, 2014
1C8U	CRYSTAL STRUCTURE OF THE E.COLI THIOESTERASE II, A HOMOLOGUE OF THE HUMAN NEF-BINDING ENZYME 分子名称: ACYL-COA THIOESTERASE II, LAURYL DIMETHYLAMINE-N-OXIDE 著者 Li, J, Derewenda, Z.S. 登録日 1999-07-29 公開日 2000-07-14 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Crystal structure of the Escherichia coli thioesterase II, a homolog of the human Nef binding enzyme. Nat.Struct.Biol., 7, 2000
3LNV	The crystal structure of fatty acyl-adenylate ligase from L. pneumophila in complex with acyl adenylate and pyrophosphate 分子名称: 5'-O-[(S)-(dodecanoyloxy)(hydroxy)phosphoryl]adenosine, PYROPHOSPHATE 2-, Saframycin Mx1 synthetase B 著者 Zhang, Z, Burley, S.K, Swaminathan, S, New York SGX Research Center for Structural Genomics (NYSGXRC) 登録日 2010-02-03 公開日 2010-04-07 最終更新日 2024-11-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structural and Functional Studies of Fatty Acyl Adenylate Ligases from E. coli and L. pneumophila. J.Mol.Biol., 406, 2011
4GUU	Crystal structure of LSD2-NPAC with tranylcypromine 分子名称: Lysine-specific histone demethylase 1B, Putative oxidoreductase GLYR1, ZINC ION, ... 著者 Chen, F, Dong, Z, Fang, J, Yang, Y, Li, Z, Xu, Y, Yang, H, Wang, P, Xu, Y. 登録日 2012-08-29 公開日 2013-01-16 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.302 Å) 主引用文献 LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation Mol.Cell, 49, 2013
2YJV	Crystal structure of E. coli regulator of ribonuclease activity A (RraA) bound to fragment of DEAD-box protein RhlB 分子名称: ATP-DEPENDENT RNA HELICASE RHLB, REGULATOR OF RIBONUCLEASE ACTIVITY A 著者 Pietras, Z, Hardwick, S.W, Luisi, B.F. 登録日 2011-05-24 公開日 2012-06-06 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Potential regulatory interactions of Escherichia coli RraA protein with DEAD-box helicases. J. Biol. Chem., 288, 2013
3EYI	The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA 分子名称: 5'-TCGCGCG-3', Z-DNA-binding protein 1 著者 Ha, S.C, Kim, K.K. 登録日 2008-10-21 公開日 2009-01-13 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to Z-DNA. Proc.Natl.Acad.Sci.USA, 105, 2008
8Z8Z	Cryo-EM structure of LYCHOS 分子名称: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... 著者 Xiong, Q, Zhu, Z, Li, T, Zhou, Z, Chao, Y, Qu, Q, Li, D. 登録日 2024-04-22 公開日 2025-01-01 最終更新日 2025-06-25 実験手法 ELECTRON MICROSCOPY (2.11 Å) 主引用文献 Molecular architecture of human LYCHOS involved in lysosomal cholesterol signaling. Nat.Struct.Mol.Biol., 32, 2025
6JOU	Crystal structure of the human nucleosome containing H2A.Z.1 S42R 分子名称: DNA (146-MER), Histone H2A.Z, Histone H2B type 1-J, ... 著者 Horikoshi, N, Sato, K, Mizukami, Y, Kurumizaka, H. 登録日 2019-03-23 公開日 2020-03-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.17 Å) 主引用文献 Structure-based design of an H2A.Z.1 mutant stabilizing a nucleosome in vitro and in vivo. Biochem.Biophys.Res.Commun., 515, 2019

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