2FMO

Ala177Val mutant of E. coli Methylenetetrahydrofolate Reductase

Summary for 2FMO

• Entry DOI: 10.2210/pdb2fmo/pdb
• Related: 2FMN
• Descriptor: 5,10-methylenetetrahydrofolate reductase, SULFATE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
• Functional Keywords: oxidoreductase, tim barrel, flavin, reductase
• Biological source: Escherichia coli
• Total number of polymer chains: 3
• Total formula weight: 105923.19

Authors

Pejchal, R.,Campbell, E.,Guenther, B.D.,Lennon, B.W.,Matthews, R.G.,Ludwig, M.L. (deposition date: 2006-01-09, release date: 2006-04-25, Last modification date: 2023-08-30)

• Primary citation: Pejchal, R.,Campbell, E.,Guenther, B.D.,Lennon, B.W.,Matthews, R.G.,Ludwig, M.L.; Structural Perturbations in the Ala -> Val Polymorphism of Methylenetetrahydrofolate Reductase: How Binding of Folates May Protect against Inactivation; Biochemistry, 45:4808-4818, 2006; PubMed: 16605249; DOI: 10.1021/bi052294c

Experimental method

X-RAY DIFFRACTION (2.25 Å)