3RV8

Structure of a M. tuberculosis Salicylate Synthase, MbtI, in Complex with an Inhibitor with Cyclopropyl R-Group

Summary for 3RV8

Entry DOI	10.2210/pdb3rv8/pdb
Related	3RV6 3RV7 3RV9
Descriptor	Isochorismate synthase/isochorismate-pyruvate lyase mbtI, 3-{[(Z)-1-carboxy-2-cyclopropylethenyl]oxy}-2-hydroxybenzoic acid, 3-{[(E)-1-carboxy-2-cyclopropylethenyl]oxy}-2-hydroxybenzoic acid, ... (4 entities in total)
Functional Keywords	structural genomics, tb structural genomics consortium, tbsgc, salicylate synthase, chorismate binding, isomerase-isomerase inhibitor complex, isomerase/isomerase inhibitor
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	4
Total formula weight	196566.11
Authors	Chi, G.,Bulloch, E.M.M.,Manos-Turvey, A.,Payne, R.J.,Lott, J.S.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2011-05-06, release date: 2012-05-09, Last modification date: 2024-03-20)
Primary citation	Chi, G.,Manos-Turvey, A.,O'Connor, P.D.,Johnston, J.M.,Evans, G.L.,Baker, E.N.,Payne, R.J.,Lott, J.S.,Bulloch, E.M. Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis Biochemistry, 51:4868-4879, 2012 Cited by PubMed: 22607697 DOI: 10.1021/bi3002067 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.29 Å)

Structure validation