PDB: 1345 件ウェブページステータス検索Chemie searchBIRD

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6PQ3	Crystal structure of GDP-bound KRAS with ten residues long internal tandem duplication in the switch II region 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... 著者 Dharmaiah, S, Chan, A.H, Tran, T.H, Simanshu, D.K. 登録日 2019-07-08 公開日 2020-05-20 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 RASinternal tandem duplication disrupts GTPase-activating protein (GAP) binding to activate oncogenic signaling. J.Biol.Chem., 295, 2020
7T1F	Crystal structure of GDP-bound T50I mutant of human KRAS4B 分子名称: GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION 著者 Zhang, Y, Zhang, C. 登録日 2021-12-01 公開日 2022-12-14 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation. JCI Insight, 8, 2023
7TAM	HRas G12V in complex with GDP 分子名称: CALCIUM ION, GTPase HRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Kouidmi, I, Maddalena, M, Laplante, S. 登録日 2021-12-21 公開日 2022-12-28 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Structure of HRas G12V in complex with GDP To Be Published
6Q21	MOLECULAR SWITCH FOR SIGNAL TRANSDUCTION: STRUCTURAL DIFFERENCES BETWEEN ACTIVE AND INACTIVE FORMS OF PROTOONCOGENIC RAS PROTEINS 分子名称: C-H-RAS P21 PROTEIN CATALYTIC DOMAIN, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER 著者 Kim, S.-H. 登録日 1992-07-27 公開日 1992-07-28 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins. Science, 247, 1990
6QUU	Crystal Structure of KRAS-G12D in complex with GMP-PCP 分子名称: GTPase KRas, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER 著者 Fischer, G, Kessler, D, Muellauer, B, Wolkerstorfer, B. 登録日 2019-02-28 公開日 2019-07-31 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.477 Å) 主引用文献 KRAS Binders Hidden in Nature. Chemistry, 25, 2019
6QUW	Crystal Structure of KRAS-G12D in Complex with Natural Product-Like Compound 9b 分子名称: (3~{a}~{R},8~{b}~{S})-2,2,3~{a},8~{b}-tetramethyl-3,4-dihydro-1~{H}-pyrrolo[2,3-b]indole, GTPase KRas, MAGNESIUM ION, ... 著者 Fischer, G, Kessler, D, Muellauer, B, Wolkerstorfer, B. 登録日 2019-02-28 公開日 2019-07-31 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.242 Å) 主引用文献 KRAS Binders Hidden in Nature. Chemistry, 25, 2019
6Q82	Crystal structure of the biportin Pdr6 in complex with RanGTP 分子名称: GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, Importin beta-like protein KAP122, ... 著者 Aksu, M, Vera-Rodriguez, A, Trakhanov, S, Gorlich, D. 登録日 2018-12-14 公開日 2019-05-01 最終更新日 2019-06-12 実験手法 X-RAY DIFFRACTION (2.994 Å) 主引用文献 Structural basis for the nuclear import and export functions of the biportin Pdr6/Kap122. J.Cell Biol., 218, 2019
6QUV	Crystal Structure of KRAS-G12D in complex with GMP-PCP and compound 15R 分子名称: (6~{a}~{R},11~{b}~{S})-6~{a}-(1,4-dimethylpiperidin-4-yl)-7,11~{b}-dihydro-6~{H}-indolo[2,3-c]isoquinolin-5-one, GTPase KRas, MAGNESIUM ION, ... 著者 Fischer, G, Kessler, D, Muellauer, B, Wolkerstorfer, B. 登録日 2019-02-28 公開日 2019-07-31 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.475 Å) 主引用文献 KRAS Binders Hidden in Nature. Chemistry, 25, 2019
6QUX	Crystal Structure of KRAS-G12D in Complex with Natural Product-Like Compound 15 分子名称: (6~{a}~{R},11~{b}~{S})-6~{a}-(1,4-dimethylpiperidin-4-yl)-7,11~{b}-dihydro-6~{H}-indolo[2,3-c]isoquinolin-5-one, 1,2-ETHANEDIOL, GTPase KRas, ... 著者 Fischer, G, Kessler, D, Muellauer, B, Wolkerstorfer, B. 登録日 2019-02-28 公開日 2019-07-31 最終更新日 2024-05-15 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 KRAS Binders Hidden in Nature. Chemistry, 25, 2019
7TLE	Crystal Structure of small molecule beta-lactone 1 covalently bound to K-Ras(G12S) 分子名称: (3R,4R)-1-[7-(8-chloronaphthalen-1-yl)-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]-3-hydroxypiperidine-4-carbaldehyde, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Ziyang, Z, Guiley, K.Z, Shokat, K.M. 登録日 2022-01-18 公開日 2022-08-03 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.98716748 Å) 主引用文献 Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S). Nat.Chem.Biol., 18, 2022
7TLK	Crystal Structure of K-Ras(G12S) 分子名称: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION 著者 Ziyang, Z, Guiley, K.Z, Shokat, K.M. 登録日 2022-01-18 公開日 2022-08-03 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.71102226 Å) 主引用文献 Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S). Nat.Chem.Biol., 18, 2022
7TLG	Crystal Structure of small molecule beta-lactone 5 covalently bound to K-Ras(G12S) 分子名称: (3R,4R)-1-[7-(8-chloronaphthalen-1-yl)-8-fluoro-2-{[(4S,7as)-tetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-4-yl]-3-hydroxypiperidine-4-carbaldehyde, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Ziyang, Z, Guiley, K.Z, Shokat, K.M. 登録日 2022-01-18 公開日 2022-08-03 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.80000722 Å) 主引用文献 Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S). Nat.Chem.Biol., 18, 2022
7U8H	Discovery of a KRAS G12V Inhibitor in vivo Tool Compound starting from an HSQC-NMR based Fragment Hit 分子名称: 1H-benzimidazol-2-ylmethanethiol, 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile, GTPase KRas, ... 著者 Phan, J, Fesik, S.W. 登録日 2022-03-08 公開日 2022-11-09 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.702 Å) 主引用文献 Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRAS G12C Inhibitor. J.Med.Chem., 65, 2022
6S5H	Structure of the human RAB38 in complex with GTP 分子名称: 1,2-ETHANEDIOL, BROMIDE ION, GUANOSINE-5'-TRIPHOSPHATE, ... 著者 Diaz-Saez, L, Jung, S, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Huber, K, Structural Genomics Consortium (SGC) 登録日 2019-07-01 公開日 2020-07-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of the human RAB38 in complex with GTP To Be Published
7VV9	Crystal Structure of HRas(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1 分子名称: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Zheng, Y.Y, Zhou, C. 登録日 2021-11-05 公開日 2022-05-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural insights into Ras regulation by SIN1. Proc.Natl.Acad.Sci.USA, 119, 2022
7VVG	Crystal Structure of HRasG12V(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1 分子名称: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Zheng, Y.Y, Zhou, C. 登録日 2021-11-06 公開日 2022-05-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural insights into Ras regulation by SIN1. Proc.Natl.Acad.Sci.USA, 119, 2022
7VV8	Crystal Structure of HRasQ61L(GMPPNP-bound) in complex with the Ras-binding domain(RBD) of SIN1 分子名称: GTPase HRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Zheng, Y.Y, Zhou, C. 登録日 2021-11-04 公開日 2022-05-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural insights into Ras regulation by SIN1. Proc.Natl.Acad.Sci.USA, 119, 2022
6S5F	Structure of the human RAB39B in complex with GMPPNP 分子名称: 1,2-ETHANEDIOL, GLYCINE, MAGNESIUM ION, ... 著者 Diaz-Saez, L, Jung, S, von Delft, F, Arrowsmith, C.H, Edwards, A, Bountra, C, Huber, K, Structural Genomics Consortium (SGC) 登録日 2019-07-01 公開日 2020-07-22 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure of the human RAB39B in complex with GMPPNP To Be Published
6GOE	KRAS full length G12V GPPNHP 分子名称: GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER 著者 Cruz-Migoni, A, Quevedo, C.E, Carr, S.B, Ehebauer, M.T, Phillips, S.V.E, Rabbitts, T.H. 登録日 2018-06-01 公開日 2019-02-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
8PIY	NMR2 Structure of KRAS G12V (GMPPNP bound) in complex with (2E)-3-(1H-indol-2-yl)prop-2-enoic acid 分子名称: (~{E})-3-(1~{H}-indol-3-yl)prop-2-enoic acid, RASK GTPase (Fragment) 著者 Buetikofer, M, Orts, J. 登録日 2023-06-22 公開日 2024-07-10 実験手法 SOLUTION NMR 主引用文献 NMR2 Structure of KRAS G12V (GMPPNP bound) in complex with 5-(1H-indol-2-l)piperazin-2-one To Be Published
6GOG	KRAS-169 Q61H GPPNHP 分子名称: CITRIC ACID, GTPase KRas, MAGNESIUM ION, ... 著者 Cruz-Migoni, A, Quevedo, C.E, Carr, S.B, Phillips, S.V.E, Rabbitts, T.H. 登録日 2018-06-01 公開日 2019-02-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6GJ5	CRYSTAL STRUCTURE OF KRAS G12D (GPPCP) IN COMPLEX WITH 15 分子名称: (3~{S})-3-[2-[(2~{R})-pyrrolidin-2-yl]-1~{H}-indol-3-yl]-2,3-dihydroisoindol-1-one, GTPase KRas, MAGNESIUM ION, ... 著者 Kessler, D, Mcconnell, D.M, Mantoulidis, A. 登録日 2018-05-16 公開日 2019-07-31 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.499 Å) 主引用文献 Drugging an undruggable pocket on KRAS. Proc.Natl.Acad.Sci.USA, 116, 2019
6GOF	KRAS full length G12D GPPNHP 分子名称: GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER 著者 Cruz-Migoni, A, Quevedo, C.E, Carr, S.B, Ehebauer, M.T, Phillips, S.V.E, Rabbitts, T.H. 登録日 2018-06-01 公開日 2019-02-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
6GQW	KRAS-169 Q61H GPPNHP + CH-1 分子名称: GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... 著者 Cruz-Migoni, A, Quevedo, C.E, Carr, S.B, Phillips, S.E.V, Rabbitts, T.H. 登録日 2018-06-08 公開日 2019-02-06 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
8QUG	KRAS-G12C in Complex with Compound 1 分子名称: (4S)-2-azanyl-4-methyl-4-[3-[2-[(2S)-2-methyl-1,4-diazepan-1-yl]pyrimidin-4-yl]-1,2,4-oxadiazol-5-yl]-6,7-dihydro-5H-1-benzothiophene-3-carbonitrile, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... 著者 Fischer, G, Kratochvil, B. 登録日 2023-10-16 公開日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.56 Å) 主引用文献 Targeting cancer with small molecule pan-KRAS degraders Biorxiv, 2023

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