6QUX

Crystal Structure of KRAS-G12D in Complex with Natural Product-Like Compound 15

Summary for 6QUX

Entry DOI	10.2210/pdb6qux/pdb
Descriptor	GTPase KRas, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	ppi, kras, gtpase, cancer, oncoprotein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	40336.31
Authors	Fischer, G.,Kessler, D.,Muellauer, B.,Wolkerstorfer, B. (deposition date: 2019-02-28, release date: 2019-07-31, Last modification date: 2019-09-25)
Primary citation	Bergner, A.,Cockcroft, X.,Fischer, G.,Gollner, A.,Hela, W.,Kousek, R.,Mantoulidis, A.,Martin, L.J.,Mayer, M.,Mullauer, B.,Siszler, G.,Wolkerstorfer, B.,Kessler, D.,McConnell, D.B. KRAS Binders Hidden in Nature. Chemistry, 25:12037-12041, 2019 Cited by PubMed: 31231840 DOI: 10.1002/chem.201902810 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.62 Å)

Structure validation