7TLG

Crystal Structure of small molecule beta-lactone 5 covalently bound to K-Ras(G12S)

Summary for 7TLG

• Entry DOI: 10.2210/pdb7tlg/pdb
• Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, (3R,4R)-1-[7-(8-chloronaphthalen-1-yl)-8-fluoro-2-{[(4S,7as)-tetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-4-yl]-3-hydroxypiperidine-4-carbaldehyde, ... (5 entities in total)
• Functional Keywords: ras, oncoprotein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 40760.58

Authors

Ziyang, Z.,Guiley, K.Z.,Shokat, K.M. (deposition date: 2022-01-18, release date: 2022-08-03, Last modification date: 2023-10-18)

• Primary citation: Zhang, Z.,Guiley, K.Z.,Shokat, K.M.; Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S).; Nat.Chem.Biol., 18:1177-1183, 2022; PubMed: 35864332; DOI: 10.1038/s41589-022-01065-9

Experimental method

X-RAY DIFFRACTION (1.80000720583 Å)