7TLK

Crystal Structure of K-Ras(G12S)

Summary for 7TLK

Entry DOI	10.2210/pdb7tlk/pdb
Descriptor	GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	ras, oncoprotein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	39538.58
Authors	Ziyang, Z.,Guiley, K.Z.,Shokat, K.M. (deposition date: 2022-01-18, release date: 2022-08-03, Last modification date: 2023-10-18)
Primary citation	Zhang, Z.,Guiley, K.Z.,Shokat, K.M. Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S). Nat.Chem.Biol., 18:1177-1183, 2022 Cited by PubMed: 35864332 DOI: 10.1038/s41589-022-01065-9 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.71102224586 Å)

Structure validation