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7TLE

Crystal Structure of small molecule beta-lactone 1 covalently bound to K-Ras(G12S)

Summary for 7TLE
Entry DOI10.2210/pdb7tle/pdb
DescriptorGTPase KRas, MAGNESIUM ION, (3R,4R)-1-[7-(8-chloronaphthalen-1-yl)-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]-3-hydroxypiperidine-4-carbaldehyde, ... (6 entities in total)
Functional Keywordsras, oncoprotein
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight20379.30
Authors
Ziyang, Z.,Guiley, K.Z.,Shokat, K.M. (deposition date: 2022-01-18, release date: 2022-08-03, Last modification date: 2023-10-18)
Primary citationZhang, Z.,Guiley, K.Z.,Shokat, K.M.
Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S).
Nat.Chem.Biol., 18:1177-1183, 2022
Cited by
PubMed: 35864332
DOI: 10.1038/s41589-022-01065-9
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.98716752773 Å)
Structure validation

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