7TLE
Crystal Structure of small molecule beta-lactone 1 covalently bound to K-Ras(G12S)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | GTPase KRas | polymer | 169 | 19279.7 | 1 | UniProt (P01116) Pfam (PF00071) In PDB | Homo sapiens (human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
2 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
3 | A | (3R,4R)-1-[7-(8-chloronaphthalen-1-yl)-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]-3-hydroxypiperidine-4-carbaldehyde | non-polymer | 536.1 | 1 | Chemie (I6T) | |||
4 | A | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
5 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
6 | water | water | 18.0 | 89 | Chemie (HOH) |
Sequence modifications
A: 1 - 164 (UniProt: P01116)
PDB | External Database | Details |
---|---|---|
Ser 12 | Gly 12 | engineered mutation |
Ser 51 | Cys 51 | conflict |
Leu 80 | Cys 80 | conflict |
Ser 118 | Cys 118 | conflict |
Gly 151 | Arg 151 | conflict |
Asp 153 | Glu 153 | conflict |
Lys 165 | - | expression tag |
His 166 | - | expression tag |
Lys 167 | - | expression tag |
Glu 168 | - | expression tag |
Lys 169 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 19279.7 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1099.6 | |
All* | Total formula weight | 20379.3 |