7T1F
Crystal structure of GDP-bound T50I mutant of human KRAS4B
Summary for 7T1F
Entry DOI | 10.2210/pdb7t1f/pdb |
Descriptor | Isoform 2B of GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | kras, ras, t50i, kras4b, k-ras, oncoprotein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 3 |
Total formula weight | 59449.42 |
Authors | |
Primary citation | Chen, P.Y.,Huang, B.J.,Harris, M.,Boone, C.,Wang, W.,Carias, H.,Mesiona, B.,Mavrici, D.,Kohler, A.C.,Bollag, G.,Zhang, C.,Zhang, Y.,Shannon, K. Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation. JCI Insight, 8:-, 2023 Cited by PubMed: 37681415DOI: 10.1172/jci.insight.168445 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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