7T1F

Crystal structure of GDP-bound T50I mutant of human KRAS4B

Summary for 7T1F

• Entry DOI: 10.2210/pdb7t1f/pdb
• Descriptor: Isoform 2B of GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: kras, ras, t50i, kras4b, k-ras, oncoprotein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 59449.42

Authors

Zhang, Y.,Zhang, C. (deposition date: 2021-12-01, release date: 2022-12-14, Last modification date: 2023-12-27)

• Primary citation: Chen, P.Y.,Huang, B.J.,Harris, M.,Boone, C.,Wang, W.,Carias, H.,Mesiona, B.,Mavrici, D.,Kohler, A.C.,Bollag, G.,Zhang, C.,Zhang, Y.,Shannon, K.; Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation.; JCI Insight, 8:-, 2023; PubMed: 37681415; DOI: 10.1172/jci.insight.168445

Experimental method

X-RAY DIFFRACTION (2.2 Å)