PDB: 379 件ウェブページステータス検索Chemie searchBIRD

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5K7L	Single particle cryo-EM structure of the voltage-gated K+ channel Eag1 bound to the channel inhibitor calmodulin 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calmodulin, ... 著者 Whicher, J.R, MacKinnon, R. 登録日 2016-05-26 公開日 2016-08-17 最終更新日 2020-07-29 実験手法 ELECTRON MICROSCOPY (3.78 Å) 主引用文献 Structure of the voltage-gated K+ channel Eag1 reveals an alternative voltage sensing mechanism. Science, 353, 2016
5JR7	Crystal structure of an ACRDYS heterodimer [RIa(92-365):C] of PKA 分子名称: ADENOSINE-5'-DIPHOSPHATE, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase type I-alpha regulatory subunit 著者 Bruystens, J.G.H, Wu, J, Taylor, S.S. 登録日 2016-05-05 公開日 2017-03-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (3.56 Å) 主引用文献 Structure of a PKA RI alpha Recurrent Acrodysostosis Mutant Explains Defective cAMP-Dependent Activation. J. Mol. Biol., 428, 2016
5JON	Crystal structure of the unliganded form of HCN2 CNBD 分子名称: Maltose-binding periplasmic protein,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, NITRATE ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose 著者 Klenchin, V.A, Chanda, B. 登録日 2016-05-02 公開日 2016-11-30 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.042 Å) 主引用文献 Structure and dynamics underlying elementary ligand binding events in human pacemaking channels. Elife, 5, 2016
5JIZ	PKG II's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with 8-pCPT-cGMP 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 2-amino-8-[(4-chlorophenyl)sulfanyl]-9-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-3,9-dihydro-6H-purin-6-one, CALCIUM ION, ... 著者 Campbell, J.C, Kim, C.W. 登録日 2016-04-22 公開日 2017-05-03 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 PKG II's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with 8-pCPT-cGMP To Be Published
5JIX	PKG II's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with 8-Br-cGMP 分子名称: 1,2-ETHANEDIOL, 2-amino-8-bromo-9-[(2R,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-1,9-dihydro-6H-purin-6-one, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, ... 著者 Campbell, J.C, Kim, C.W. 登録日 2016-04-22 公開日 2017-05-03 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Structural Basis of Analog Specificity in PKG I and II. ACS Chem. Biol., 12, 2017
5JD7	PKG I's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with PET-cGMP 分子名称: 3-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-6-phenyl-3,4-dihydro-9H-imidazo[1,2-a]purin-9-one, cGMP-dependent protein kinase 1 著者 Campbell, J.C, Sankaran, B, Kim, C.W. 登録日 2016-04-15 公開日 2017-08-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.749 Å) 主引用文献 Structural Basis of Analog Specificity in PKG I and II. ACS Chem. Biol., 12, 2017
5JAX	PKG I's Carboyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with 8-Br-cGMP 分子名称: 2-amino-8-bromo-9-[(2R,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-1,9-dihydro-6H-purin-6-one, CALCIUM ION, SODIUM ION, ... 著者 Campbell, J.C, Sankaran, B, Kim, C.W. 登録日 2016-04-12 公開日 2017-04-19 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.486 Å) 主引用文献 Structural Basis of Analog Specificity in PKG I and II. ACS Chem. Biol., 12, 2017
5J48	PKG I's Carboyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with 8-pCPT-cGMP 分子名称: 1,2-ETHANEDIOL, 2-amino-8-[(4-chlorophenyl)sulfanyl]-9-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-3,9-dihydro-6H-purin-6-one, CALCIUM ION, ... 著者 Campbell, J.C, Sankaran, B, Kim, C.W. 登録日 2016-03-31 公開日 2017-04-12 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.49 Å) 主引用文献 Structural Basis of Analog Specificity in PKG I and II. ACS Chem. Biol., 12, 2017
5J3U	Co-crystal structure of the regulatory domain of Toxoplasma gondii PKA with cAMP 分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, GLYCEROL, Protein Kinase A 著者 El Bakkouri, M, Walker, J.R, Tempel, W, Loppnau, P, Graslund, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Lin, L, Structural Genomics Consortium (SGC) 登録日 2016-03-31 公開日 2016-04-20 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Co-crystal structure of the regulatory domain of Toxoplasma gondii PKA with cAMP To Be Published
5I2D	Crystal structure of T. thermophilus TTHB099 class II transcription activation complex: TAP-RPo 分子名称: DNA (72-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Feng, Y, Zhang, Y, Ebright, R.H. 登録日 2016-02-08 公開日 2016-06-22 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (4.405 Å) 主引用文献 Structural basis of transcription activation. Science, 352, 2016
5H5O	A cyclic-GMP-dependent signalling pathway regulates bacterial phytopathogenesis 分子名称: CYCLIC GUANOSINE MONOPHOSPHATE, Diguanylate cyclase 著者 Chin, K.H, Chou, S.-H. 登録日 2016-11-08 公開日 2017-05-24 実験手法 X-RAY DIFFRACTION (2.122 Å) 主引用文献 A cyclic GMP-dependent signalling pathway regulates bacterial phytopathogenesis EMBO J., 32, 2013
5H3O	Structure of a eukaryotic cyclic nucleotide-gated channel 分子名称: CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel, SODIUM ION 著者 Li, M, Zhou, X, Wang, S, Michailidis, I, Gong, Y, Su, D, Li, H, Li, X, Yang, J. 登録日 2016-10-26 公開日 2017-01-25 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structure of a eukaryotic cyclic-nucleotide-gated channel. Nature, 542, 2017
5FET	Crystal Structure of PVX_084705 in presence of Compound 2 分子名称: 4-[7-[(dimethylamino)methyl]-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]pyrimidin-2-amine, cGMP-dependent protein kinase, putative 著者 Wernimont, A.K, Tempel, W, Walker, J.R, He, H, Seitova, A, Hills, T, Neculai, A.M, Baker, D.A, Flueck, C, Kettleborough, C.A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Hutchinson, A, El Bakkouri, M, Structural Genomics Consortium (SGC) 登録日 2015-12-17 公開日 2016-01-13 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (3.07 Å) 主引用文献 Crystal Structure of PVX_084705 in presence of Compound 2 To be published
5F0A	CRYSTAL STRUCTURE OF PVX_084705 WITH BOUND 1-tert-butyl-3-(3-chlorophenoxy)-1H-pyrazolo[3,4-d]pyrimidin-4-amine INHIBITOR 分子名称: 1-tert-butyl-3-(3-chlorophenoxy)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, cGMP-dependent protein kinase, putative 著者 Walker, J.R, Wernimont, A.K, He, H, Seitova, A, Loppnau, P, Sibley, L.D, Graslund, S, Hutchinson, A, Bountra, C, Weigelt, J, Edwards, A.M, Arrowsmith, C.H, Hui, R, El Bakkouri, M, Structural Genomics Consortium (SGC) 登録日 2015-11-27 公開日 2015-12-16 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 CRYSTAL STRUCTURE OF PVX_084705 WITH BOUND INHIBITOR To be published
5EZR	Crystal Structure of PVX_084705 bound to compound 分子名称: CHLORIDE ION, N-[5-(3-{2-[(cyclopropylmethyl)amino]pyrimidin-4-yl}-7-[(dimethylamino)methyl]-6-methylimidazo[1,2-a]pyridin-2-yl)-2-fluorophenyl]methanesulfonamide, cGMP-dependent protein kinase, ... 著者 El Bakkouri, M, Amani, M, Walker, J.R, Osborne, S, Large, J.M, Birchall, K, Bouloc, N, Smiljanic-Hurley, E, Wheldon, M, Harding, D.J, Merritt, A.T, Ansell, K.H, Coombs, P.J, Kettleborough, C.A, Stewart, B.L, Bowyer, P.W, Gutteridge, W.E, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Baker, D.A, Hui, R, Loppnau, P, Structural Genomics Consortium (SGC) 登録日 2015-11-26 公開日 2017-05-10 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal Structure of PVX_084705 bound to compound To Be Published
5E44	Crystal structure of holo-FNR of A. fischeri 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, FNR regulator, IRON/SULFUR CLUSTER 著者 Volbeda, A, Fontecilla-Camps, J.C. 登録日 2015-10-05 公開日 2015-12-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 The crystal structure of the global anaerobic transcriptional regulator FNR explains its extremely fine-tuned monomer-dimer equilibrium. Sci Adv, 1, 2015
5E16	Co-crystal structure of the N-termial cGMP binding domain of Plasmodium falciparum PKG with cGMP 分子名称: CGMP-dependent protein kinase, CYCLIC GUANOSINE MONOPHOSPHATE 著者 El Bakkouri, M, Walker, J.R, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Structural Genomics Consortium (SGC) 登録日 2015-09-29 公開日 2015-11-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation. Proc.Natl.Acad.Sci.USA, 116, 2019
5DZC	Crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium Vivax - AMPPNP bound 分子名称: CHLORIDE ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SODIUM ION, ... 著者 Walker, J.R, El Bakkouri, M, Loppnau, P, Graslund, S, He, H, Seitova, A, Hutchinson, A, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Hui, R, Amani, M, Structural Genomics Consortium (SGC) 登録日 2015-09-25 公開日 2015-10-14 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation. Proc.Natl.Acad.Sci.USA, 116, 2019
5DYL	Crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium Vivax - Apo form 分子名称: cGMP-dependent protein kinase, putative 著者 Wernimont, A.K, Tempel, W, He, H, Seitova, A, Hills, T, Neculai, A.M, Baker, D.A, Flueck, C, Kettleborough, C.A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Hutchinson, A, El Bakkouri, M, Structural Genomics Consortium (SGC) 登録日 2015-09-24 公開日 2015-11-04 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation. Proc.Natl.Acad.Sci.USA, 116, 2019
5DYK	Crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium falciparum - Apo form 分子名称: 1,2-ETHANEDIOL, CGMP-dependent protein kinase, GLYCEROL, ... 著者 Wernimont, A.K, Tempel, W, He, H, Seitova, A, Hills, T, Neculai, A.M, Baker, D.A, Flueck, C, Kettleborough, C.A, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Hui, R, Hutchinson, A, El Bakkouri, M, Structural Genomics Consortium (SGC) 登録日 2015-09-24 公開日 2015-11-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation. Proc.Natl.Acad.Sci.USA, 116, 2019
5D1I	Structure of Cyclic nucleotide-binding-like protein from Brucella abortus bv. 1 str. 9-941 分子名称: Cyclic nucleotide-binding protein 著者 He, Z, Dong, J, Li, X, Gao, Y. 登録日 2015-08-04 公開日 2015-09-09 最終更新日 2016-01-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structure of cyclic nucleotide-binding-like protein from Brucella abortus Biochem.Biophys.Res.Commun., 468, 2015
5CVR	Crystal structure of FNR of A. fischeri in a partially degraded form 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, FE2/S2 (INORGANIC) CLUSTER, FNR type regulator 著者 Volbeda, A, Fontecilla-Camps, J.C. 登録日 2015-07-27 公開日 2015-12-16 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 The crystal structure of the global anaerobic transcriptional regulator FNR explains its extremely fine-tuned monomer-dimer equilibrium. Sci Adv, 1, 2015
5CIZ	E. coli RNA polymerase alpha subunit CTD in complex with CAP and DNA: A(5)-tract binding site for alpha CTD 分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, DNA (5'-D(*CP*TP*AP*GP*AP*TP*CP*AP*CP*AP*TP*TP*TP*TP*AP*GP*GP*CP*AP*AP*AP*AP*AP*G)-3'), DNA (5'-D(*CP*TP*TP*TP*TP*TP*GP*CP*CP*TP*AP*AP*AP*AP*TP*GP*TP*GP*AP*T)-3'), ... 著者 Napoli, A.A, Lawson, C.L. 登録日 2015-07-13 公開日 2016-06-29 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (5.0098 Å) 主引用文献 The RNA Polymerase alpha Subunit Recognizes the DNA Shape of the Upstream Promoter Element Biochemistry, 2020
5C8W	PKG II's Amino Terminal Cyclic Nucleotide Binding Domain (CNB-A) in a complex with cGMP 分子名称: CYCLIC GUANOSINE MONOPHOSPHATE, MALONIC ACID, SODIUM ION, ... 著者 Campbell, J.C, Reger, A.S, Huang, G.Y, Sankaran, B, Kim, J.J, Kim, C.W. 登録日 2015-06-26 公開日 2016-01-20 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II. J.Biol.Chem., 291, 2016
5C6C	PKG II's Amino Terminal Cyclic Nucleotide Binding Domain (CNB-A) in a complex with cAMP 分子名称: 1,2-ETHANEDIOL, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CADMIUM ION, ... 著者 Campbell, J.C, Reger, A.S, Huang, G.Y, Sankaran, B, Kim, J.J, Kim, C.W. 登録日 2015-06-22 公開日 2016-01-20 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II. J.Biol.Chem., 291, 2016

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