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7L2X
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cryo-EM structure of RTX-bound minimal TRPV1 with NMDG at state c
分子名称: (10R,13S)-16-amino-13-hydroxy-7,13-dioxo-8,12,14-trioxa-13lambda~5~-phosphahexadecan-10-yl hexadecanoate, 1-deoxy-1-(methylamino)-D-allitol, Transient receptor potential cation channel subfamily V member 1, ...
著者Zhang, K, Julius, D, Cheng, Y.
登録日2020-12-17
公開日2021-09-22
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.26 Å)
主引用文献Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.
Cell, 184, 2021
3J5P
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Structure of TRPV1 ion channel determined by single particle electron cryo-microscopy
分子名称: Transient receptor potential cation channel subfamily V member 1
著者Liao, M, Cao, E, Julius, D, Cheng, Y.
登録日2013-10-28
公開日2013-12-04
最終更新日2024-02-21
実験手法ELECTRON MICROSCOPY (3.275 Å)
主引用文献Structure of the TRPV1 ion channel determined by electron cryo-microscopy.
Nature, 504, 2013
3J9J
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Structure of the capsaicin receptor, TRPV1, determined by single particle electron cryo-microscopy
分子名称: Transient receptor potential cation channel subfamily V member 1
著者Wang, R.Y.-R, Barad, B.A, Fraser, J.S, DiMaio, F.
登録日2015-02-02
公開日2015-09-02
最終更新日2024-02-21
実験手法ELECTRON MICROSCOPY (3.275 Å)
主引用文献EMRinger: side chain-directed model and map validation for 3D cryo-electron microscopy.
Nat.Methods, 12, 2015
5Z96
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Structure of the mouse TRPC4 ion channel
分子名称: 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, CHOLESTEROL HEMISUCCINATE, SODIUM ION, ...
著者Duan, J, Li, Z, Li, J, Zhang, J.
登録日2018-02-02
公開日2018-04-18
最終更新日2018-08-29
実験手法ELECTRON MICROSCOPY (3.28 Å)
主引用文献Structure of the mouse TRPC4 ion channel.
Nat Commun, 9, 2018
6JZO
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BU of 6jzo by Molmil
Structure of the mouse TRPC4 ion channel
分子名称: 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, CHOLESTEROL HEMISUCCINATE, SODIUM ION, ...
著者Duan, J, Li, Z, Li, J, Zhang, J.
登録日2019-05-03
公開日2020-10-21
最終更新日2021-05-05
実験手法ELECTRON MICROSCOPY (3.28 Å)
主引用文献Structure of the mouse TRPC4 ion channel
To Be Published
5IRZ
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Structure of TRPV1 determined in lipid nanodisc
分子名称: (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4S,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(pentanoyloxy)propan-2-yl decanoate, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, ...
著者Gao, Y, Cao, E, Julius, D, Cheng, Y.
登録日2016-03-15
公開日2016-05-25
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.28 Å)
主引用文献TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534, 2016
5Y4D
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Crystal Structure of AnkB Ankyrin Repeats in Complex with AnkR/AnkB Chimeric Autoinhibition Segment
分子名称: Ankyrin-1,Ankyrin-2,Ankyrin-2, SULFATE ION
著者Chen, K, Li, J, Wang, C, Wei, Z, Zhang, M.
登録日2017-08-03
公開日2017-09-13
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Autoinhibition of ankyrin-B/G membrane target bindings by intrinsically disordered segments from the tail regions.
Elife, 6, 2017
6LGP
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cryo-EM structure of TRPV3 in lipid nanodisc
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, DIUNDECYL PHOSPHATIDYL CHOLINE, Transient receptor potential cation channel subfamily V member 3
著者Shimada, H, Kusakizako, T, Nishizawa, T, Nureki, O.
登録日2019-12-05
公開日2020-06-24
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献The structure of lipid nanodisc-reconstituted TRPV3 reveals the gating mechanism.
Nat.Struct.Mol.Biol., 27, 2020
6V9X
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Structure of TRPA1 modified by iodoacetamide, PMAL-C8
分子名称: Transient receptor potential cation channel subfamily A member 1
著者Zhao, J, Lin King, J.V, Paulsen, C.E, Cheng, Y, Julius, D.
登録日2019-12-16
公開日2020-05-06
最終更新日2020-09-16
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Irritant-evoked activation and calcium modulation of the TRPA1 receptor.
Nature, 585, 2020
8T0E
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TRPV1 in Nanodisc not bound with lysophosphatidic acid (apo)
分子名称: (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1
著者Arnold, W.R, Cheng, Y.
登録日2023-05-31
公開日2024-05-08
最終更新日2024-05-15
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural basis of TRPV1 modulation by endogenous bioactive lipids.
Nat.Struct.Mol.Biol., 2024
6O20
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Cryo-EM structure of TRPV5 with calmodulin bound
分子名称: CALCIUM ION, Calmodulin, Transient receptor potential cation channel subfamily V member 5
著者Dang, S, van Goor, M.K, Asarnow, D, Wang, Y, Julius, D, Cheng, Y, van der Wijst, J.
登録日2019-02-22
公開日2019-04-24
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural insight into TRPV5 channel function and modulation.
Proc.Natl.Acad.Sci.USA, 116, 2019
8FC7
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BU of 8fc7 by Molmil
Cryo-EM structure of the human TRPV4 - RhoA in complex with GSK2798745
分子名称: 1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Kwon, D.H, Lee, S.-Y, Zhang, F.
登録日2022-12-01
公開日2023-07-12
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease.
Nat Commun, 14, 2023
7XUF
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BU of 7xuf by Molmil
Cryo-EM structure of the AKT1-AtKC1 complex from Arabidopsis thaliana
分子名称: POTASSIUM ION, Potassium channel AKT1, Potassium channel KAT3
著者Yang, G.H, Lu, Y.M, Jia, Y.T, Yang, F, Zhang, Y.M, Xu, X, Li, X.M, Lei, J.L.
登録日2022-05-18
公開日2022-11-09
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural basis for the activity regulation of a potassium channel AKT1 from Arabidopsis.
Nat Commun, 13, 2022
7L2R
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BU of 7l2r by Molmil
Cryo-EM structure of DkTx-bound minimal TRPV1 at the pre-open state
分子名称: (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, (9R,12R)-15-amino-12-hydroxy-6,12-dioxo-7,11,13-trioxa-12lambda~5~-phosphapentadecan-9-yl undecanoate, SODIUM ION, ...
著者Zhang, K, Julius, D, Cheng, Y.
登録日2020-12-17
公開日2021-09-22
最終更新日2021-10-13
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.
Cell, 184, 2021
7RQZ
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Cryo-EM structure of the full-length TRPV1 with RTx at 48 degrees Celsius, in an open state, class alpha
分子名称: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, ...
著者Kwon, D.H, Suo, Y, Lee, S.-Y.
登録日2021-08-08
公開日2022-06-01
実験手法ELECTRON MICROSCOPY (3.32 Å)
主引用文献Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis.
Nat Commun, 13, 2022
4OT9
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crystal structure of the C-terminal domain of p100/NF-kB2
分子名称: Nuclear factor NF-kappa-B p100 subunit, SULFATE ION
著者Tao, Z.H, Huang, D.B, Fusco, A, Gupta, K, Ware, C.F, Duynne, G.V.
登録日2014-02-13
公開日2015-01-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.35 Å)
主引用文献p100/I kappa B delta sequesters and inhibits NF-kappa B through kappaBsome formation.
Proc.Natl.Acad.Sci.USA, 111, 2014
7MZ7
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BU of 7mz7 by Molmil
Cryo-EM structure of minimal TRPV1 with 4 partially bound RTX
分子名称: SODIUM ION, Transient receptor potential cation channel subfamily V member 1, resiniferatoxin
著者Zhang, K, Julius, D, Cheng, Y.
登録日2021-05-24
公開日2021-09-22
最終更新日2021-10-13
実験手法ELECTRON MICROSCOPY (3.35 Å)
主引用文献Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.
Cell, 184, 2021
8T1D
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BU of 8t1d by Molmil
Open-state cryo-EM structure of full-length human TRPV4 in complex with agonist 4a-PDD
分子名称: (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera
著者Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I.
登録日2023-06-02
公開日2023-07-05
実験手法ELECTRON MICROSCOPY (3.35 Å)
主引用文献Structure of human TRPV4 in complex with GTPase RhoA.
Nat Commun, 14, 2023
7RQX
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Cryo-EM structure of the full-length TRPV1 with RTx at 25 degrees Celsius, in an intermediate-open state, class A
分子名称: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ...
著者Kwon, D.H, Suo, Y, Lee, S.-Y.
登録日2021-08-08
公開日2022-06-01
実験手法ELECTRON MICROSCOPY (3.36 Å)
主引用文献Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis.
Nat Commun, 13, 2022
7LPA
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BU of 7lpa by Molmil
Cryo-EM structure of full-length TRPV1 with capsaicin at 4 degrees Celsius
分子名称: (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, ...
著者Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y.
登録日2021-02-11
公開日2021-07-28
実験手法ELECTRON MICROSCOPY (3.37 Å)
主引用文献Heat-dependent opening of TRPV1 in the presence of capsaicin.
Nat.Struct.Mol.Biol., 28, 2021
7T6Q
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BU of 7t6q by Molmil
Cryo-EM structure of TRPV5 T709D with PI(4,5)P2 in nanodiscs
分子名称: Transient receptor potential cation channel subfamily V member 5, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
著者Fluck, E.C, Yazici, A.T, Rohacs, T, Moiseenkova-Bell, V.Y.
登録日2021-12-14
公開日2022-05-04
最終更新日2024-02-28
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural basis of TRPV5 regulation by physiological and pathophysiological modulators.
Cell Rep, 39, 2022
8WUI
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SKOR D312N L271P double mutation
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Potassium channel SKOR
著者Gao, X, Sun, T, Lu, Y, Jia, Y, Xu, X, Zhang, Y, Fu, P, Yang, G.
登録日2023-10-20
公開日2024-04-10
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural changes in the conversion of an Arabidopsis outward-rectifying K + channel into an inward-rectifying channel.
Plant Commun., 2024
6MHO
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Structure of the human TRPV3 channel in the apo conformation
分子名称: Transient receptor potential cation channel subfamily V member 3
著者Zubcevic, L, Herzik, M.A, Wu, M, Borschel, W.F, Hirschi, M, Song, A, Lander, G.C, Lee, S.Y.
登録日2018-09-18
公開日2018-10-03
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Conformational ensemble of the human TRPV3 ion channel.
Nat Commun, 9, 2018
7WSW
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BU of 7wsw by Molmil
Cryo-EM structure of the Potassium channel AKT1 from Arabidopsis thaliana
分子名称: PHOSPHATIDYLETHANOLAMINE, POTASSIUM ION, Potassium channel AKT1
著者Yang, G.H, Lu, Y.M, Zhang, Y.M, Jia, Y.T, Li, X.M, Lei, J.L.
登録日2022-02-02
公開日2022-11-09
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural basis for the activity regulation of a potassium channel AKT1 from Arabidopsis.
Nat Commun, 13, 2022
7LQZ
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Structure of squirrel TRPV1 in complex with RTX
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Osm-9-like TRP channel 1, SODIUM ION, ...
著者Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I.
登録日2021-02-15
公開日2021-04-21
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.41 Å)
主引用文献Extracellular cap domain is an essential component of the TRPV1 gating mechanism.
Nat Commun, 12, 2021

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