7T6Q

Cryo-EM structure of TRPV5 T709D with PI(4,5)P2 in nanodiscs

Summary for 7T6Q

Entry DOI	10.2210/pdb7t6q/pdb
EMDB information	25716 25717 25718 25719 25720 25721 25722 25723 25724 25725
Descriptor	Transient receptor potential cation channel subfamily V member 5, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (2 entities in total)
Functional Keywords	calcium, ion channel, kidney, transport protein
Biological source	Oryctolagus cuniculus (rabbit)
Total number of polymer chains	4
Total formula weight	338180.54
Authors	Fluck, E.C.,Yazici, A.T.,Rohacs, T.,Moiseenkova-Bell, V.Y. (deposition date: 2021-12-14, release date: 2022-05-04, Last modification date: 2024-02-28)
Primary citation	Fluck, E.C.,Yazici, A.T.,Rohacs, T.,Moiseenkova-Bell, V.Y. Structural basis of TRPV5 regulation by physiological and pathophysiological modulators. Cell Rep, 39:110737-110737, 2022 Cited by PubMed: 35476976 DOI: 10.1016/j.celrep.2022.110737 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.4 Å)

Structure validation