7RQX

Cryo-EM structure of the full-length TRPV1 with RTx at 25 degrees Celsius, in an intermediate-open state, class A

Summary for 7RQX

• Entry DOI: 10.2210/pdb7rqx/pdb
• EMDB information: 24639
• Descriptor: Transient receptor potential cation channel subfamily V member 1, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, ... (5 entities in total)
• Functional Keywords: ligand-gating ion channel, membrane protein
• Biological source: Rattus norvegicus (Rat)
• Total number of polymer chains: 4
• Total formula weight: 412136.40

Authors

Kwon, D.H.,Suo, Y.,Lee, S.-Y. (deposition date: 2021-08-08, release date: 2022-06-01)

• Primary citation: Kwon, D.H.,Zhang, F.,Fedor, J.G.,Suo, Y.,Lee, S.Y.; Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis.; Nat Commun, 13:2874-2874, 2022; PubMed: 35610228; DOI: 10.1038/s41467-022-30602-2

Experimental method

ELECTRON MICROSCOPY (3.36 Å)