PDB: 5515 件ウェブページステータス検索Chemie searchBIRD

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7OTU	Human OMPD-domain of UMPS in complex with 6-hydroxy-UMP at 0.95 Angstroms resolution, crystal 2 分子名称: 6-HYDROXYURIDINE-5'-PHOSPHATE, GLYCEROL, Isoform 2 of Uridine 5'-monophosphate synthase 著者 Rindfleisch, S, Rabe von Pappenheim, F, Tittmann, K. 登録日 2021-06-10 公開日 2022-04-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (0.95 Å) 主引用文献 Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis Nat Catal, 5, 2022
7Z6C	Crystal structure of human Dihydroorotate Dehydrogenase in complex with the inhibitor 2-Hydroxy-N-(2-ispropyl-5-methyl-4-phenoxyphenyl)pyrazolo[1,5-a]pyridine-3-carboxamide. 分子名称: ACETATE ION, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... 著者 Alberti, M, Lolli, M.L, Boschi, D, Sainas, S, Rizzi, M, Ferraris, D.M, Miggiano, R. 登録日 2022-03-11 公開日 2022-10-12 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5- a ]pyridine Scaffold: SAR of the Aryloxyaryl Moiety. J.Med.Chem., 65, 2022
5NX9	Crystal structure of Neanderthal Adenylosuccinate Lyase (ADSL) in complex with its products AMP and fumarate 分子名称: 2-[9-(3,4-DIHYDROXY-5-PHOSPHONOOXYMETHYL-TETRAHYDRO-FURAN-2-YL)-9H-PURIN-6-YLAMINO]-SUCCINIC ACID, ADENOSINE MONOPHOSPHATE, Adenylosuccinate lyase, ... 著者 Van Laer, B, Kapp, U, Soler-Lopez, M, Leonard, G, Mueller-Dieckmann, C. 登録日 2017-05-09 公開日 2018-05-30 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Molecular comparison of Neanderthal and Modern Human adenylosuccinate lyase. Sci Rep, 8, 2018
7ZEA	Crystal Structure of truncated aspartate transcarbamoylase from Plasmodium falciparum with bound inhibitor O-benzylhydroxylamine 分子名称: Aspartate carbamoyltransferase, O-benzylhydroxylamine, SODIUM ION, ... 著者 Wang, C, Zhang, B. 登録日 2022-03-30 公開日 2022-08-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.448 Å) 主引用文献 Discovery of Small-Molecule Allosteric Inhibitors of Pf ATC as Antimalarials. J.Am.Chem.Soc., 144, 2022
7ZCZ	Crystal Structure of truncated aspartate transcarbamoylase from Plasmodium falciparum with bound inhibitor 1-(4-chlorophenyl)methanamine 分子名称: 1-(4-CHLOROPHENYL)METHANAMINE, Aspartate carbamoyltransferase, SODIUM ION, ... 著者 Wang, C, Zhang, B. 登録日 2022-03-29 公開日 2022-08-31 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Discovery of Small-Molecule Allosteric Inhibitors of Pf ATC as Antimalarials. J.Am.Chem.Soc., 144, 2022
7ZHI	Crystal Structure of truncated aspartate transcarbamoylase from Plasmodium falciparum with bound inhibitor indole 分子名称: Aspartate carbamoyltransferase, INDOLE, SULFATE ION 著者 Wang, C, Zhang, B. 登録日 2022-04-06 公開日 2022-08-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.946 Å) 主引用文献 Discovery of Small-Molecule Allosteric Inhibitors of Pf ATC as Antimalarials. J.Am.Chem.Soc., 144, 2022
7ZP2	Crystal Structure of truncated aspartate transcarbamoylase from Plasmodium falciparum in complex with BDA-04 分子名称: Aspartate carbamoyltransferase, SODIUM ION, SULFATE ION, ... 著者 Wang, C, Zhang, B, Groves, M.R. 登録日 2022-04-26 公開日 2022-08-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.292 Å) 主引用文献 Discovery of Small-Molecule Allosteric Inhibitors of Pf ATC as Antimalarials. J.Am.Chem.Soc., 144, 2022
7ZGS	Crystal Structure of truncated aspartate transcarbamoylase from Plasmodium falciparum with bound inhibitor 2-phenylethan-1-amine 分子名称: 3-PHENYLPROPYLAMINE, Aspartate carbamoyltransferase, SODIUM ION, ... 著者 Wang, C, Zhang, B. 登録日 2022-04-04 公開日 2022-08-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.349 Å) 主引用文献 Discovery of Small-Molecule Allosteric Inhibitors of Pf ATC as Antimalarials. J.Am.Chem.Soc., 144, 2022
7ZST	Crystal Structure of truncated aspartate transcarbamoylase from Plasmodium falciparum in complex with FLA-01 分子名称: 2-azanyl-~{N}-(2-methoxyethyl)-5-phenyl-thiophene-3-carboxamide, Aspartate carbamoyltransferase, GLYCEROL, ... 著者 Wang, C, Zhang, B, Groves, M.R. 登録日 2022-05-08 公開日 2022-08-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Discovery of Small-Molecule Allosteric Inhibitors of Pf ATC as Antimalarials. J.Am.Chem.Soc., 144, 2022
7ZID	Crystal Structure of truncated aspartate transcarbamoylase from Plasmodium falciparum in complex with BDA-14 分子名称: Aspartate carbamoyltransferase, GLYCEROL, SULFATE ION, ... 著者 Wang, C, Zhang, B. 登録日 2022-04-07 公開日 2022-08-31 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Discovery of Small-Molecule Allosteric Inhibitors of Pf ATC as Antimalarials. J.Am.Chem.Soc., 144, 2022
2VHI	Crystal structure of a pyrimidine degrading enzyme from Drosophila melanogaster 分子名称: CG3027-PA 著者 Lundgren, S, Lohkamp, B, Andersen, B, Piskur, J, Dobritzsch, D. 登録日 2007-11-21 公開日 2008-03-25 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 The Crystal Structure of Beta-Alanine Synthase from Drosophila Melanogaster Reveals a Homooctameric Helical Turn-Like Assembly. J.Mol.Biol., 377, 2008
2VRH	Structure of the E. coli trigger factor bound to a translating ribosome 分子名称: 50S RIBOSOMAL PROTEIN L23, 50S RIBOSOMAL PROTEIN L24, 50S RIBOSOMAL PROTEIN L29, ... 著者 Merz, F, Boehringer, D, Schaffitzel, C, Preissler, S, Hoffmann, A, Maier, T, Rutkowska, A, Lozza, J, Ban, N, Bukau, B, Deuerling, E. 登録日 2008-04-07 公開日 2008-06-17 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (19 Å) 主引用文献 Molecular Mechanism and Structure of Trigger Factor Bound to the Translating Ribosome. Embo J., 27, 2008
5KSW	DHODB-I74D mutant 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Dihydroorotate dehydrogenase, ... 著者 Pompeu, Y.A, Stewart, J.D. 登録日 2016-07-10 公開日 2016-08-03 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (2.47 Å) 主引用文献 Isoleucine 74 Plays a Key Role in Controlling Electron Transfer Between Lactococcus lactis Dihydroorotate Dehydrogenase 1B Subunits To Be Published
5MVC	Crystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on hydroxylated azole scaffolds 分子名称: 4-oxidanyl-~{N}-[2,3,5,6-tetrakis(fluoranyl)-4-phenyl-phenyl]-1,2,5-thiadiazole-3-carboxamide, ACETATE ION, CHLORIDE ION, ... 著者 Goyal, P, Andersson, M, Moritzer, A.C, Sainas, S, Pippione, A.C, Boschi, D, Al-Kadaraghi, S, Lolli, M, Friemann, R. 登録日 2017-01-16 公開日 2017-03-08 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds. Eur J Med Chem, 129, 2017
5MUT	Crystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on hydroxylated azole scaffolds 分子名称: 2-methyl-5-oxidanyl-~{N}-[2,3,5,6-tetrakis(fluoranyl)-4-phenyl-phenyl]-1,2,3-triazole-4-carboxamide, ACETATE ION, CHLORIDE ION, ... 著者 Goyal, P, Andersson, M, Moritzer, A.C, Sainas, S, Pippione, A.C, Boschi, D, Al-Kadaraghi, S, Lolli, M, Friemann, R. 登録日 2017-01-14 公開日 2017-03-08 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds. Eur J Med Chem, 129, 2017
5MVD	Crystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on hydroxylated azole scaffolds 分子名称: 1,5-dimethyl-3-oxidanyl-~{N}-[2,3,5,6-tetrakis(fluoranyl)-4-phenyl-phenyl]pyrazole-4-carboxamide, ACETATE ION, CHLORIDE ION, ... 著者 Goyal, P, Andersson, M, Moritzer, A.C, Sainas, S, Pippione, A.C, Boschi, D, Al-Kadaraghi, S, Lolli, M, Friemann, R. 登録日 2017-01-16 公開日 2017-03-08 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds. Eur J Med Chem, 129, 2017
2CZ5	Crystal structure of orotidine 5'-phosphate decarboxylase from Pyrococcus horikoshii OT3 分子名称: CITRIC ACID, GLYCEROL, Orotidine 5'-phosphate decarboxylase 著者 Arai, R, Ito, K, Kamo-Uchikubo, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-07-11 公開日 2006-01-11 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Crystal structure of orotidine 5'-phosphate decarboxylase from Pyrococcus horikoshii OT3 To be Published
2EAW	Human UMP Synthase (C-terminal Domain- Orotidine 5'-Monophosphate Decarboxylase) 分子名称: SULFATE ION, Uridine 5'-monophosphate synthase 著者 Liu, Y, Tang, H.L, Pai, E.F. 登録日 2007-02-03 公開日 2007-02-13 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.88 Å) 主引用文献 Human UMP Synthase (C-terminal Domain - Orotidine 5'-Monophosphate Decarboxylase) TO BE PUBLISHED
2E6Y	Covalent complex of orotidine 5'-monophosphate decarboxylase (ODCase) with 6-Iodo-UMP 分子名称: GLYCEROL, Orotidine 5'-phosphate decarboxylase, URIDINE-5'-MONOPHOSPHATE 著者 Fujihashi, M, Bello, A.M, Kotra, L.P, Pai, E.F. 登録日 2007-01-05 公開日 2007-02-27 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 A Potent, Covalent Inhibitor of Orotidine 5'-Monophosphate Decarboxylase with Antimalarial Activity. J.Med.Chem., 50, 2007
2E25	The Crystal Structure of the T109S mutant of E. coli Dihydroorotase complexed with an inhibitor 5-fluoroorotate 分子名称: 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, Dihydroorotase, ZINC ION 著者 Lee, M, Maher, M.J, Guss, J.M. 登録日 2006-11-08 公開日 2007-03-13 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structure of the T109S mutant of Escherichia coli dihydroorotase complexed with the inhibitor 5-fluoroorotate: catalytic activity is reflected by the crystal form Acta Crystallogr.,Sect.F, 63, 2007
2FZG	The Structure of Wild-Type E. Coli Aspartate Transcarbamoylase in Complex with Novel T State Inhibitors at 2.25 Resolution 分子名称: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ... 著者 Heng, S, Stieglitz, K.A, Eldo, J, Xia, J, Cardia, J.P, Kantrowitz, E.R. 登録日 2006-02-09 公開日 2006-08-29 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 T-state Inhibitors of E. coli Aspartate Transcarbamoylase that Prevent the Allosteric Transition. Biochemistry, 45, 2006
2F84	Crystal Structure of an orotidine-5'-monophosphate decarboxylase homolog from P.falciparum 分子名称: PHOSPHATE ION, orotidine monophosphate decarboxylase 著者 Caruthers, J.M, Robein, M, Merritt, E.A, Hol, W.G.J, Structural Genomics of Pathogenic Protozoa Consortium (SGPP) 登録日 2005-12-01 公開日 2005-12-20 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal Structure of an orotidine-5'-monophosphate decarboxylase homolog from Plasmodium falciparum To be Published
2FZK	The Structure of Wild-Type E. Coli Aspartate Transcarbamoylase in Complex with Novel T State Inhibitors at 2.50 Resolution 分子名称: 3,5-BIS[(PHOSPHONOACETYL)AMINO]BENZOIC ACID, Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, ... 著者 Heng, S, Stieglitz, K.A, Eldo, J, Xia, J, Cardia, J.P, Kantrowitz, E.R. 登録日 2006-02-09 公開日 2006-08-29 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 T-state Inhibitors of E. coli Aspartate Transcarbamoylase that Prevent the Allosteric Transition. Biochemistry, 45, 2006
2FZC	The Structure of Wild-Type E. Coli Aspartate Transcarbamoylase in Complex with Novel T State Inhibitors at 2.10 Resolution 分子名称: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, CYTIDINE-5'-TRIPHOSPHATE, ... 著者 Heng, S, Stieglitz, K.A, Eldo, J, Xia, J, Cardia, J.P, Kantrowitz, E.R. 登録日 2006-02-09 公開日 2006-08-29 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 T-state Inhibitors of E. coli Aspartate Transcarbamoylase that Prevent the Allosteric Transition. Biochemistry, 45, 2006
2H3E	Structure of wild-type E. coli Aspartate Transcarbamoylase in the presence of N-phosphonacetyl-L-isoasparagine at 2.3A resolution 分子名称: (S)-4-AMINO-4-OXO-3-(2-PHOSPHONOACETAMIDO)BUTANOIC ACID, Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, ... 著者 Eldo, J, Cardia, J.P, O'Day, E.M, Xia, J, Tsuruta, H, Kantrowitz, E.R. 登録日 2006-05-22 公開日 2006-10-17 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 N-Phosphonacetyl-l-isoasparagine a Potent and Specific Inhibitor of Escherichia coli Aspartate Transcarbamoylase. J.Med.Chem., 49, 2006

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