7ZGS

Crystal Structure of truncated aspartate transcarbamoylase from Plasmodium falciparum with bound inhibitor 2-phenylethan-1-amine

Summary for 7ZGS

Entry DOI	10.2210/pdb7zgs/pdb
Descriptor	Aspartate carbamoyltransferase, 3-PHENYLPROPYLAMINE, SODIUM ION, ... (5 entities in total)
Functional Keywords	aspartate transcarbamoylase, plasmodium falciparum, fragment-based screening, inhibitor, malaria, transferase
Biological source	Plasmodium falciparum 3D7
Total number of polymer chains	3
Total formula weight	121673.02
Authors	Wang, C.,Zhang, B. (deposition date: 2022-04-04, release date: 2022-08-24, Last modification date: 2024-01-31)
Primary citation	Wang, C.,Zhang, B.,Kruger, A.,Du, X.,Visser, L.,Domling, A.S.S.,Wrenger, C.,Groves, M.R. Discovery of Small-Molecule Allosteric Inhibitors of Pf ATC as Antimalarials. J.Am.Chem.Soc., 144:19070-19077, 2022 Cited by PubMed: 36195578 DOI: 10.1021/jacs.2c08128 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.349 Å)

Structure validation