7ZST

Crystal Structure of truncated aspartate transcarbamoylase from Plasmodium falciparum in complex with FLA-01

Summary for 7ZST

Entry DOI	10.2210/pdb7zst/pdb
Descriptor	Aspartate carbamoyltransferase, GLYCEROL, SULFATE ION, ... (6 entities in total)
Functional Keywords	aspartate transcarbamoylase, plasmodium falciparum, fragment-based screening, inhibitor, malaria, transferase
Biological source	Plasmodium falciparum 3D7
Total number of polymer chains	3
Total formula weight	121727.94
Authors	Wang, C.,Zhang, B.,Groves, M.R. (deposition date: 2022-05-08, release date: 2022-08-24, Last modification date: 2024-01-31)
Primary citation	Wang, C.,Zhang, B.,Kruger, A.,Du, X.,Visser, L.,Domling, A.S.S.,Wrenger, C.,Groves, M.R. Discovery of Small-Molecule Allosteric Inhibitors of Pf ATC as Antimalarials. J.Am.Chem.Soc., 144:19070-19077, 2022 Cited by PubMed: 36195578 DOI: 10.1021/jacs.2c08128 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation