7ZST

Crystal Structure of truncated aspartate transcarbamoylase from Plasmodium falciparum in complex with FLA-01

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Aspartate carbamoyltransferase	polymer	349	40350.8	3	UniProt (A0A5K1K910) Pfam (PF02729) Pfam (PF00185) In PDB	Plasmodium falciparum 3D7
2	A	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
3	A, B	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	A	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
5	B	2-azanyl-~{N}-(2-methoxyethyl)-5-phenyl-thiophene-3-carboxamide	non-polymer		276.4	1	Chemie (JUF)
6		water	water		18.0	44	Chemie (HOH)

Sequence modifications

A, B, C: 37 - 375 (UniProt: A0A5K1K910)

PDB	External Database	Details
Ser 376	-	expression tag
Ala 377	-	expression tag
Trp 378	-	expression tag
Ser 379	-	expression tag
His 380	-	expression tag
Pro 381	-	expression tag
Gln 382	-	expression tag
Phe 383	-	expression tag
Glu 384	-	expression tag
Lys 385	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	121052.3
Non-Polymers*	Number of molecules	6
	Total formula weight	675.7
All*	Total formula weight	121727.9

*Water molecules are not included.