5MVD
Crystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on hydroxylated azole scaffolds
Summary for 5MVD
Entry DOI | 10.2210/pdb5mvd/pdb |
Descriptor | Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (7 entities in total) |
Functional Keywords | dhodh, human dhodh, oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Mitochondrion inner membrane ; Single-pass membrane protein : Q02127 |
Total number of polymer chains | 1 |
Total formula weight | 40712.30 |
Authors | Goyal, P.,Andersson, M.,Moritzer, A.C.,Sainas, S.,Pippione, A.C.,Boschi, D.,Al-Kadaraghi, S.,Lolli, M.,Friemann, R. (deposition date: 2017-01-16, release date: 2017-03-08, Last modification date: 2024-01-17) |
Primary citation | Sainas, S.,Pippione, A.C.,Giorgis, M.,Lupino, E.,Goyal, P.,Ramondetti, C.,Buccinna, B.,Piccinini, M.,Braga, R.C.,Andrade, C.H.,Andersson, M.,Moritzer, A.C.,Friemann, R.,Mensa, S.,Al-Kadaraghi, S.,Boschi, D.,Lolli, M.L. Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds. Eur J Med Chem, 129:287-302, 2017 Cited by PubMed: 28235702DOI: 10.1016/j.ejmech.2017.02.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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