7ZP2
Crystal Structure of truncated aspartate transcarbamoylase from Plasmodium falciparum in complex with BDA-04
Summary for 7ZP2
| Entry DOI | 10.2210/pdb7zp2/pdb |
| Descriptor | Aspartate carbamoyltransferase, tert-butyl N-[5-phenyl-3-(2-phenylethylcarbamoyl)thiophen-2-yl]carbamate, SULFATE ION, ... (5 entities in total) |
| Functional Keywords | aspartate transcarbamoylase, plasmodium falciparum, fragment-based screening, inhibitor, malaria, transferase |
| Biological source | Plasmodium falciparum 3D7 |
| Total number of polymer chains | 6 |
| Total formula weight | 242957.34 |
| Authors | Wang, C.,Zhang, B.,Groves, M.R. (deposition date: 2022-04-26, release date: 2022-08-24, Last modification date: 2024-01-31) |
| Primary citation | Wang, C.,Zhang, B.,Kruger, A.,Du, X.,Visser, L.,Domling, A.S.S.,Wrenger, C.,Groves, M.R. Discovery of Small-Molecule Allosteric Inhibitors of Pf ATC as Antimalarials. J.Am.Chem.Soc., 144:19070-19077, 2022 Cited by PubMed: 36195578DOI: 10.1021/jacs.2c08128 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.292 Å) |
Structure validation
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