5MVC

Crystal structure of potent human Dihydroorotate Dehydrogenase inhibitors based on hydroxylated azole scaffolds

Summary for 5MVC

Entry DOI	10.2210/pdb5mvc/pdb
Descriptor	Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (7 entities in total)
Functional Keywords	dhodh, human dhodh, oxidoreductase
Biological source	Homo sapiens (Human)
Cellular location	Mitochondrion inner membrane ; Single-pass membrane protein : Q02127
Total number of polymer chains	1
Total formula weight	43913.50
Authors	Goyal, P.,Andersson, M.,Moritzer, A.C.,Sainas, S.,Pippione, A.C.,Boschi, D.,Al-Kadaraghi, S.,Lolli, M.,Friemann, R. (deposition date: 2017-01-16, release date: 2017-03-08, Last modification date: 2024-01-17)
Primary citation	Sainas, S.,Pippione, A.C.,Giorgis, M.,Lupino, E.,Goyal, P.,Ramondetti, C.,Buccinna, B.,Piccinini, M.,Braga, R.C.,Andrade, C.H.,Andersson, M.,Moritzer, A.C.,Friemann, R.,Mensa, S.,Al-Kadaraghi, S.,Boschi, D.,Lolli, M.L. Design, synthesis, biological evaluation and X-ray structural studies of potent human dihydroorotate dehydrogenase inhibitors based on hydroxylated azole scaffolds. Eur J Med Chem, 129:287-302, 2017 Cited by PubMed: 28235702 DOI: 10.1016/j.ejmech.2017.02.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation