8WP0
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![BU of 8wp0 by Molmil](/molmil-images/mine/8wp0) | Structure of the Arabidopsis E529Q/E1174Q ABCB19 in the ATP bound state | 分子名称: | ABC transporter B family member 19, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION | 著者 | Ying, W, Wei, H, Liu, X, Sun, L. | 登録日 | 2023-10-08 | 公開日 | 2024-03-13 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export. Science, 383, 2024
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8UKR
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![BU of 8ukr by Molmil](/molmil-images/mine/8ukr) | RNA polymerase II elongation complex with Fapy-dG lesion soaking with ATP before chemistry | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, ... | 著者 | Hou, P, Oh, J, Wang, D. | 登録日 | 2023-10-15 | 公開日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (3.78 Å) | 主引用文献 | Molecular Mechanism of RNA Polymerase II Transcriptional Mutagenesis by the Epimerizable DNA Lesion, Fapy·dG. J.Am.Chem.Soc., 146, 2024
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8XGR
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![BU of 8xgr by Molmil](/molmil-images/mine/8xgr) | ETB-eGt complex bound to endothelin-1 | 分子名称: | Camelid antibody VHH fragment, Endothelin receptor type B, Endothelin-1, ... | 著者 | Oshima, H.S, Sano, F.K, Akasaka, H, Iwama, A, Shihoya, W, Nureki, O. | 登録日 | 2023-12-15 | 公開日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Optimizing cryo-EM structural analysis of G i -coupling receptors via engineered G t and Nb35 application. Biochem.Biophys.Res.Commun., 693, 2024
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8W7F
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![BU of 8w7f by Molmil](/molmil-images/mine/8w7f) | Structure of Drosophila melanogaster L-2-hydroxyglutarate dehydrogenase bound with FAD and a sulfate ion | 分子名称: | DODECYL-BETA-D-MALTOSIDE, FI05204p, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Yang, J, Chen, X, Jin, S, Ding, J. | 登録日 | 2023-08-30 | 公開日 | 2023-11-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.299 Å) | 主引用文献 | Structure and biochemical characterization of l-2-hydroxyglutarate dehydrogenase and its role in the pathogenesis of l-2-hydroxyglutaric aciduria. J.Biol.Chem., 300, 2023
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8W6P
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![BU of 8w6p by Molmil](/molmil-images/mine/8w6p) | Crystal structure of dimeric murine SMPDL3A | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Acid sphingomyelinase-like phosphodiesterase 3a, ... | 著者 | Zhang, C, Liu, P, Fan, S, Hou, Y. | 登録日 | 2023-08-29 | 公開日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS-STING DNA sensing. Immunity, 56, 2023
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8UKU
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![BU of 8uku by Molmil](/molmil-images/mine/8uku) | RNA polymerase II elongation complex with Fapy-dG lesion with CMP added | 分子名称: | DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ... | 著者 | Hou, P, Oh, J, Wang, D. | 登録日 | 2023-10-15 | 公開日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Molecular Mechanism of RNA Polymerase II Transcriptional Mutagenesis by the Epimerizable DNA Lesion, Fapy·dG. J.Am.Chem.Soc., 146, 2024
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8WWV
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![BU of 8wwv by Molmil](/molmil-images/mine/8wwv) | 1-naphthylamine GS in complex with ADP and MetSox-P | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Glutamine synthetase, L-METHIONINE-S-SULFOXIMINE PHOSPHATE, ... | 著者 | Zhang, S.T, Zhou, N.Y. | 登録日 | 2023-10-26 | 公開日 | 2024-01-03 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discovery of the 1-naphthylamine biodegradation pathway reveals a glutamine synthetase-like protein that catalyzes 1-naphthylamine glutamylation To Be Published
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8UQ6
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8X9E
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![BU of 8x9e by Molmil](/molmil-images/mine/8x9e) | Crystal structure of CO dehydrogenase mutant with increased affinity for electron mediators in low PEG concentration | 分子名称: | 1,2-ETHANEDIOL, Carbon monoxide dehydrogenase 2, FE (III) ION, ... | 著者 | Lee, H.H, Heo, Y, Yoon, H.J, Kim, S.M, Kong, S.Y. | 登録日 | 2023-11-30 | 公開日 | 2024-04-17 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Identifying a key spot for electron mediator-interaction to tailor CO dehydrogenase's affinity. Nat Commun, 15, 2024
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8TQX
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8V5W
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![BU of 8v5w by Molmil](/molmil-images/mine/8v5w) | UIC-1 mutant UIC-1-B5T | 分子名称: | UIC-1-B5T | 著者 | Heinz-Kunert, S.L. | 登録日 | 2023-12-01 | 公開日 | 2024-03-06 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.07 Å) | 主引用文献 | Pore Restructuring of Peptide Frameworks by Mutations at Distal Packing Residues. Biomacromolecules, 25, 2024
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8W4S
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![BU of 8w4s by Molmil](/molmil-images/mine/8w4s) | Crystal structure of PDE5A in complex with CVT-313 | 分子名称: | 2,2'-{[6-{[(4-methoxyphenyl)methyl]amino}-9-(propan-2-yl)-9H-purin-2-yl]azanediyl}di(ethan-1-ol), MAGNESIUM ION, ZINC ION, ... | 著者 | Liu, J.Y, Li, M.J, Xu, Y.C. | 登録日 | 2023-08-24 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.848 Å) | 主引用文献 | Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors. Eur.J.Med.Chem., 262, 2023
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9CE9
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9AYF
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![BU of 9ayf by Molmil](/molmil-images/mine/9ayf) | Structure of human calcium-sensing receptor in complex with Gi1 (miniGi1) protein in detergent | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine, ... | 著者 | Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R. | 登録日 | 2024-03-07 | 公開日 | 2024-04-17 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Promiscuous G-protein activation by the calcium-sensing receptor. Nature, 629, 2024
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8VRN
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![BU of 8vrn by Molmil](/molmil-images/mine/8vrn) | Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus PPTQ | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(4-methylphenyl)-2-phenylquinazolin-4(3H)-one, ... | 著者 | Chojnacka, W, Teng, J, Kim, J.J, Jensen, A.A, Hibbs, R.E. | 登録日 | 2024-01-22 | 公開日 | 2024-06-26 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (2.57 Å) | 主引用文献 | Structural insights into GABA A receptor potentiation by Quaalude. Nat Commun, 15, 2024
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8W4T
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![BU of 8w4t by Molmil](/molmil-images/mine/8w4t) | Crystal structure of PDE5A in complex with a novel inhibitor | 分子名称: | 2-[bis(2-hydroxyethyl)amino]-6-[(4-methoxyphenyl)methylamino]-9-propan-2-yl-7~{H}-purin-8-one, MAGNESIUM ION, ZINC ION, ... | 著者 | Liu, J.Y, Li, M.J, Xu, Y.C. | 登録日 | 2023-08-24 | 公開日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.199 Å) | 主引用文献 | Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors. Eur.J.Med.Chem., 262, 2023
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8VBW
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![BU of 8vbw by Molmil](/molmil-images/mine/8vbw) | Structure of the monofunctional Staphylococcus aureus PBP1 in its beta-lactam (Ertapenem) inhibited form | 分子名称: | (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Penicillin-binding protein 1 | 著者 | Bon, C.G, Lee, J, Caveney, N.A, Strynadka, N.C.J. | 登録日 | 2023-12-12 | 公開日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1. J.Struct.Biol., 216, 2024
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8TSV
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8XK2
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![BU of 8xk2 by Molmil](/molmil-images/mine/8xk2) | A neutralizing nanobody VHH60 against wt SARS-CoV-2 | 分子名称: | Spike protein S1, VHH60 nanobody | 著者 | Lu, Y, Guo, H, Ji, X, Yang, H. | 登録日 | 2023-12-22 | 公開日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | A broad neutralizing nanobody against SARS-CoV-2 engineered from an approved drug. Cell Death Dis, 15, 2024
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8WZM
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8YJJ
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8VM2
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![BU of 8vm2 by Molmil](/molmil-images/mine/8vm2) | Crystal Structure of NRAS Q61K bound to GTP | 分子名称: | GTPase NRas, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Gebregiworgis, T, Chan, J.Y.L, Kuntz, D.A, Prive, G.G, Marshall, C.B, Ikura, M. | 登録日 | 2024-01-12 | 公開日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Crystal structure of NRAS Q61K with a ligand-induced pocket near switch II. Eur J Cell Biol, 103, 2024
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9FBV
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8WZH
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8VRW
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![BU of 8vrw by Molmil](/molmil-images/mine/8vrw) | Cryo-EM structure of human invariant chain in complex with HLA-DR15 | 分子名称: | HLA class II histocompatibility antigen gamma chain, HLA class II histocompatibility antigen, DR alpha chain, ... | 著者 | Wang, N, Caveney, N.A, Jude, K.M, Garcia, K.C. | 登録日 | 2024-01-22 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | 主引用文献 | Structural insights into human MHC-II association with invariant chain. Proc.Natl.Acad.Sci.USA, 121, 2024
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