8VBW

Structure of the monofunctional Staphylococcus aureus PBP1 in its beta-lactam (Ertapenem) inhibited form

Summary for 8VBW

• Entry DOI: 10.2210/pdb8vbw/pdb
• Descriptor: Penicillin-binding protein 1, (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid (3 entities in total)
• Functional Keywords: penicillin binding protein 1, peptidoglycan transpeptidase domain, pedestal domain, membrane protein, hydrolase-inhibitor, antibiotic complex, hydrolase/inhibitor, antibiotic
• Biological source: Staphylococcaceae bacterium
• Total number of polymer chains: 2
• Total formula weight: 134243.58

Authors

Bon, C.G.,Lee, J.,Caveney, N.A.,Strynadka, N.C.J. (deposition date: 2023-12-12, release date: 2024-05-01)

• Primary citation: Bon, C.G.,Grigg, J.C.,Lee, J.,Robb, C.S.,Caveney, N.A.,Eltis, L.D.,Strynadka, N.C.J.; Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1.; J.Struct.Biol., 216:108086-108086, 2024; PubMed: 38527711; DOI: 10.1016/j.jsb.2024.108086

Experimental method

X-RAY DIFFRACTION (2.3 Å)