8VBW
Structure of the monofunctional Staphylococcus aureus PBP1 in its beta-lactam (Ertapenem) inhibited form
Summary for 8VBW
Entry DOI | 10.2210/pdb8vbw/pdb |
Descriptor | Penicillin-binding protein 1, (4R,5S)-3-({(3S,5S)-5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl}sulfanyl)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid (3 entities in total) |
Functional Keywords | penicillin binding protein 1, peptidoglycan transpeptidase domain, pedestal domain, membrane protein, hydrolase-inhibitor, antibiotic complex, hydrolase/inhibitor, antibiotic |
Biological source | Staphylococcaceae bacterium |
Total number of polymer chains | 2 |
Total formula weight | 134243.58 |
Authors | Bon, C.G.,Lee, J.,Caveney, N.A.,Strynadka, N.C.J. (deposition date: 2023-12-12, release date: 2024-05-01) |
Primary citation | Bon, C.G.,Grigg, J.C.,Lee, J.,Robb, C.S.,Caveney, N.A.,Eltis, L.D.,Strynadka, N.C.J. Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1. J.Struct.Biol., 216:108086-108086, 2024 Cited by PubMed: 38527711DOI: 10.1016/j.jsb.2024.108086 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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