8W4T

Crystal structure of PDE5A in complex with a novel inhibitor

Summary for 8W4T

• Entry DOI: 10.2210/pdb8w4t/pdb
• Descriptor: cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: pde5a, inhibitor, complex structure, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 40597.28

Authors

Liu, J.Y.,Li, M.J.,Xu, Y.C. (deposition date: 2023-08-24, release date: 2023-11-22)

• Primary citation: Liu, J.,Zhang, X.,Chen, G.,Shao, Q.,Zou, Y.,Li, Z.,Su, H.,Li, M.,Xu, Y.; Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors.; Eur.J.Med.Chem., 262:115893-115893, 2023; PubMed: 37918035; DOI: 10.1016/j.ejmech.2023.115893

Experimental method

X-RAY DIFFRACTION (2.199 Å)