8VRW

Cryo-EM structure of human invariant chain in complex with HLA-DR15

Summary for 8VRW

• Entry DOI: 10.2210/pdb8vrw/pdb
• EMDB information: 43488
• Descriptor: HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1 beta chain, HLA class II histocompatibility antigen gamma chain (3 entities in total)
• Functional Keywords: antigen presentation, membrane protein, trimeric complex, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 9
• Total formula weight: 303267.23

Authors

Wang, N.,Caveney, N.A.,Jude, K.M.,Garcia, K.C. (deposition date: 2024-01-22, release date: 2024-05-08, Last modification date: 2024-05-15)

• Primary citation: Wang, N.,Waghray, D.,Caveney, N.A.,Jude, K.M.,Garcia, K.C.; Structural insights into human MHC-II association with invariant chain.; Proc.Natl.Acad.Sci.USA, 121:e2403031121-e2403031121, 2024; PubMed: 38687785; DOI: 10.1073/pnas.2403031121

Experimental method

ELECTRON MICROSCOPY (3.03 Å)