8VRW

Cryo-EM structure of human invariant chain in complex with HLA-DR15

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G	HLA class II histocompatibility antigen, DR alpha chain	polymer	288	32419.0	3	UniProt (P01903) Pfam (PF00993) Pfam (PF07654) In PDB	Homo sapiens (human)	MHC class II antigen DRA
2	B, E, H	HLA class II histocompatibility antigen, DRB1 beta chain	polymer	300	33768.2	3	UniProt (P01911) Pfam (PF00969) Pfam (PF07654) In PDB	Homo sapiens (human)	Human leukocyte antigen DRB1,HLA-DRB1
3	C, F, I	HLA class II histocompatibility antigen gamma chain	polymer	308	34901.9	3	UniProt (P04233) Pfam (PF09307) Pfam (PF08831) Pfam (PF00086) In PDB	Homo sapiens (human)	HLA-DR antigens-associated invariant chain,Ia antigen-associated invariant chain,Ii

Sequence modifications

A, D, G: -24 - 229 (UniProt: P01903)

PDB	External Database	Details
Ala 230	-	expression tag
Ala 231	-	expression tag
Ala 232	-	expression tag
Leu 233	-	expression tag
Glu 234	-	expression tag
Val 235	-	expression tag
Leu 236	-	expression tag
Phe 237	-	expression tag
Gln 238	-	expression tag
Gly 239	-	expression tag
Pro 240	-	expression tag
Gly 241	-	expression tag
Ala 242	-	expression tag
Ala 243	-	expression tag
Glu 244	-	expression tag
Asp 245	-	expression tag
Gln 246	-	expression tag
Val 247	-	expression tag
Asp 248	-	expression tag
Pro 249	-	expression tag
Arg 250	-	expression tag
Leu 251	-	expression tag
Ile 252	-	expression tag
Asp 253	-	expression tag
Gly 254	-	expression tag
Lys 255	-	expression tag
His 256	-	expression tag
His 257	-	expression tag
His 258	-	expression tag
His 259	-	expression tag
His 260	-	expression tag
His 261	-	expression tag
His 262	-	expression tag
His 263	-	expression tag

B, E, H: -28 - 237 (UniProt: P01911)

PDB	External Database	Details
Ala 238	-	expression tag
Ala 239	-	expression tag
Ala 240	-	expression tag
Leu 241	-	expression tag
Glu 242	-	expression tag
Val 243	-	expression tag
Leu 244	-	expression tag
Phe 245	-	expression tag
Gln 246	-	expression tag
Gly 247	-	expression tag
Pro 248	-	expression tag
Gly 249	-	expression tag
Ala 250	-	expression tag
Ala 251	-	expression tag
Glu 252	-	expression tag
Asp 253	-	expression tag
Gln 254	-	expression tag
Val 255	-	expression tag
Asp 256	-	expression tag
Pro 257	-	expression tag
Arg 258	-	expression tag
Leu 259	-	expression tag
Ile 260	-	expression tag
Asp 261	-	expression tag
Gly 262	-	expression tag
Lys 263	-	expression tag
His 264	-	expression tag
His 265	-	expression tag
His 266	-	expression tag
His 267	-	expression tag
His 268	-	expression tag
His 269	-	expression tag
His 270	-	expression tag
His 271	-	expression tag

C, F, I: 2 - 296 (UniProt: P04233)

PDB	External Database	Details
Met -11	-	initiating methionine
Asp -10	-	expression tag
Tyr -9	-	expression tag
Lys -8	-	expression tag
Asp -7	-	expression tag
Asp -6	-	expression tag
Asp -5	-	expression tag
Asp -4	-	expression tag
Ala -3	-	expression tag
Gly -2	-	expression tag
Thr -1	-	expression tag
Ser 0	-	expression tag
Arg 1	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	303267.2
All*	Total formula weight	303267.2

*Water molecules are not included.