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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

8VRW

Cryo-EM structure of human invariant chain in complex with HLA-DR15

Functional Information from GO Data
ChainGOidnamespacecontents
A0006955biological_processimmune response
A0016020cellular_componentmembrane
A0019882biological_processantigen processing and presentation
A0042613cellular_componentMHC class II protein complex
B0006955biological_processimmune response
B0016020cellular_componentmembrane
B0019882biological_processantigen processing and presentation
B0042613cellular_componentMHC class II protein complex
C0000139cellular_componentGolgi membrane
C0001516biological_processprostaglandin biosynthetic process
C0001540molecular_functionamyloid-beta binding
C0001961biological_processpositive regulation of cytokine-mediated signaling pathway
C0002250biological_processadaptive immune response
C0002286biological_processT cell activation involved in immune response
C0002376biological_processimmune system process
C0002606biological_processpositive regulation of dendritic cell antigen processing and presentation
C0002792biological_processnegative regulation of peptide secretion
C0002830biological_processpositive regulation of type 2 immune response
C0002906biological_processnegative regulation of mature B cell apoptotic process
C0004896molecular_functioncytokine receptor activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005768cellular_componentendosome
C0005770cellular_componentlate endosome
C0005771cellular_componentmultivesicular body
C0005773cellular_componentvacuole
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005794cellular_componentGolgi apparatus
C0005886cellular_componentplasma membrane
C0006457biological_processprotein folding
C0006886biological_processintracellular protein transport
C0006955biological_processimmune response
C0009897cellular_componentexternal side of plasma membrane
C0009986cellular_componentcell surface
C0010628biological_processpositive regulation of gene expression
C0012507cellular_componentER to Golgi transport vesicle membrane
C0016020cellular_componentmembrane
C0016064biological_processimmunoglobulin mediated immune response
C0019882biological_processantigen processing and presentation
C0019883biological_processantigen processing and presentation of endogenous antigen
C0019955molecular_functioncytokine binding
C0023026molecular_functionMHC class II protein complex binding
C0030336biological_processnegative regulation of cell migration
C0030658cellular_componenttransport vesicle membrane
C0030666cellular_componentendocytic vesicle membrane
C0030669cellular_componentclathrin-coated endocytic vesicle membrane
C0030890biological_processpositive regulation of B cell proliferation
C0031394biological_processpositive regulation of prostaglandin biosynthetic process
C0032588cellular_componenttrans-Golgi network membrane
C0032722biological_processpositive regulation of chemokine production
C0032755biological_processpositive regulation of interleukin-6 production
C0032757biological_processpositive regulation of interleukin-8 production
C0032991cellular_componentprotein-containing complex
C0034341biological_processresponse to type II interferon
C0035691biological_processmacrophage migration inhibitory factor signaling pathway
C0035692cellular_componentmacrophage migration inhibitory factor receptor complex
C0035693cellular_componentNOS2-CD74 complex
C0035718molecular_functionmacrophage migration inhibitory factor binding
C0042289molecular_functionMHC class II protein binding
C0042609molecular_functionCD4 receptor binding
C0042613cellular_componentMHC class II protein complex
C0042658molecular_functionMHC class II protein binding, via antigen binding groove
C0042802molecular_functionidentical protein binding
C0043030biological_processregulation of macrophage activation
C0043066biological_processnegative regulation of apoptotic process
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0043202cellular_componentlysosomal lumen
C0043410biological_processpositive regulation of MAPK cascade
C0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
C0044183molecular_functionprotein folding chaperone
C0045058biological_processT cell selection
C0045657biological_processpositive regulation of monocyte differentiation
C0048146biological_processpositive regulation of fibroblast proliferation
C0050998molecular_functionnitric-oxide synthase binding
C0060907biological_processpositive regulation of macrophage cytokine production
C0065003biological_processprotein-containing complex assembly
C0070062cellular_componentextracellular exosome
C0070206biological_processprotein trimerization
C0070374biological_processpositive regulation of ERK1 and ERK2 cascade
C0090023biological_processpositive regulation of neutrophil chemotaxis
C0098553cellular_componentlumenal side of endoplasmic reticulum membrane
C1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
C2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
C2000448biological_processpositive regulation of macrophage migration inhibitory factor signaling pathway
D0006955biological_processimmune response
D0016020cellular_componentmembrane
D0019882biological_processantigen processing and presentation
D0042613cellular_componentMHC class II protein complex
E0006955biological_processimmune response
E0016020cellular_componentmembrane
E0019882biological_processantigen processing and presentation
E0042613cellular_componentMHC class II protein complex
F0000139cellular_componentGolgi membrane
F0001516biological_processprostaglandin biosynthetic process
F0001540molecular_functionamyloid-beta binding
F0001961biological_processpositive regulation of cytokine-mediated signaling pathway
F0002250biological_processadaptive immune response
F0002286biological_processT cell activation involved in immune response
F0002376biological_processimmune system process
F0002606biological_processpositive regulation of dendritic cell antigen processing and presentation
F0002792biological_processnegative regulation of peptide secretion
F0002830biological_processpositive regulation of type 2 immune response
F0002906biological_processnegative regulation of mature B cell apoptotic process
F0004896molecular_functioncytokine receptor activity
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005764cellular_componentlysosome
F0005765cellular_componentlysosomal membrane
F0005768cellular_componentendosome
F0005770cellular_componentlate endosome
F0005771cellular_componentmultivesicular body
F0005773cellular_componentvacuole
F0005783cellular_componentendoplasmic reticulum
F0005789cellular_componentendoplasmic reticulum membrane
F0005794cellular_componentGolgi apparatus
F0005886cellular_componentplasma membrane
F0006457biological_processprotein folding
F0006886biological_processintracellular protein transport
F0006955biological_processimmune response
F0009897cellular_componentexternal side of plasma membrane
F0009986cellular_componentcell surface
F0010628biological_processpositive regulation of gene expression
F0012507cellular_componentER to Golgi transport vesicle membrane
F0016020cellular_componentmembrane
F0016064biological_processimmunoglobulin mediated immune response
F0019882biological_processantigen processing and presentation
F0019883biological_processantigen processing and presentation of endogenous antigen
F0019955molecular_functioncytokine binding
F0023026molecular_functionMHC class II protein complex binding
F0030336biological_processnegative regulation of cell migration
F0030658cellular_componenttransport vesicle membrane
F0030666cellular_componentendocytic vesicle membrane
F0030669cellular_componentclathrin-coated endocytic vesicle membrane
F0030890biological_processpositive regulation of B cell proliferation
F0031394biological_processpositive regulation of prostaglandin biosynthetic process
F0032588cellular_componenttrans-Golgi network membrane
F0032722biological_processpositive regulation of chemokine production
F0032755biological_processpositive regulation of interleukin-6 production
F0032757biological_processpositive regulation of interleukin-8 production
F0032991cellular_componentprotein-containing complex
F0034341biological_processresponse to type II interferon
F0035691biological_processmacrophage migration inhibitory factor signaling pathway
F0035692cellular_componentmacrophage migration inhibitory factor receptor complex
F0035693cellular_componentNOS2-CD74 complex
F0035718molecular_functionmacrophage migration inhibitory factor binding
F0042289molecular_functionMHC class II protein binding
F0042609molecular_functionCD4 receptor binding
F0042613cellular_componentMHC class II protein complex
F0042658molecular_functionMHC class II protein binding, via antigen binding groove
F0042802molecular_functionidentical protein binding
F0043030biological_processregulation of macrophage activation
F0043066biological_processnegative regulation of apoptotic process
F0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
F0043202cellular_componentlysosomal lumen
F0043410biological_processpositive regulation of MAPK cascade
F0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
F0044183molecular_functionprotein folding chaperone
F0045058biological_processT cell selection
F0045657biological_processpositive regulation of monocyte differentiation
F0048146biological_processpositive regulation of fibroblast proliferation
F0050998molecular_functionnitric-oxide synthase binding
F0060907biological_processpositive regulation of macrophage cytokine production
F0065003biological_processprotein-containing complex assembly
F0070062cellular_componentextracellular exosome
F0070206biological_processprotein trimerization
F0070374biological_processpositive regulation of ERK1 and ERK2 cascade
F0090023biological_processpositive regulation of neutrophil chemotaxis
F0098553cellular_componentlumenal side of endoplasmic reticulum membrane
F1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
F2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
F2000448biological_processpositive regulation of macrophage migration inhibitory factor signaling pathway
G0006955biological_processimmune response
G0016020cellular_componentmembrane
G0019882biological_processantigen processing and presentation
G0042613cellular_componentMHC class II protein complex
H0006955biological_processimmune response
H0016020cellular_componentmembrane
H0019882biological_processantigen processing and presentation
H0042613cellular_componentMHC class II protein complex
I0000139cellular_componentGolgi membrane
I0001516biological_processprostaglandin biosynthetic process
I0001540molecular_functionamyloid-beta binding
I0001961biological_processpositive regulation of cytokine-mediated signaling pathway
I0002250biological_processadaptive immune response
I0002286biological_processT cell activation involved in immune response
I0002376biological_processimmune system process
I0002606biological_processpositive regulation of dendritic cell antigen processing and presentation
I0002792biological_processnegative regulation of peptide secretion
I0002830biological_processpositive regulation of type 2 immune response
I0002906biological_processnegative regulation of mature B cell apoptotic process
I0004896molecular_functioncytokine receptor activity
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005634cellular_componentnucleus
I0005737cellular_componentcytoplasm
I0005764cellular_componentlysosome
I0005765cellular_componentlysosomal membrane
I0005768cellular_componentendosome
I0005770cellular_componentlate endosome
I0005771cellular_componentmultivesicular body
I0005773cellular_componentvacuole
I0005783cellular_componentendoplasmic reticulum
I0005789cellular_componentendoplasmic reticulum membrane
I0005794cellular_componentGolgi apparatus
I0005886cellular_componentplasma membrane
I0006457biological_processprotein folding
I0006886biological_processintracellular protein transport
I0006955biological_processimmune response
I0009897cellular_componentexternal side of plasma membrane
I0009986cellular_componentcell surface
I0010628biological_processpositive regulation of gene expression
I0012507cellular_componentER to Golgi transport vesicle membrane
I0016020cellular_componentmembrane
I0016064biological_processimmunoglobulin mediated immune response
I0019882biological_processantigen processing and presentation
I0019883biological_processantigen processing and presentation of endogenous antigen
I0019955molecular_functioncytokine binding
I0023026molecular_functionMHC class II protein complex binding
I0030336biological_processnegative regulation of cell migration
I0030658cellular_componenttransport vesicle membrane
I0030666cellular_componentendocytic vesicle membrane
I0030669cellular_componentclathrin-coated endocytic vesicle membrane
I0030890biological_processpositive regulation of B cell proliferation
I0031394biological_processpositive regulation of prostaglandin biosynthetic process
I0032588cellular_componenttrans-Golgi network membrane
I0032722biological_processpositive regulation of chemokine production
I0032755biological_processpositive regulation of interleukin-6 production
I0032757biological_processpositive regulation of interleukin-8 production
I0032991cellular_componentprotein-containing complex
I0034341biological_processresponse to type II interferon
I0035691biological_processmacrophage migration inhibitory factor signaling pathway
I0035692cellular_componentmacrophage migration inhibitory factor receptor complex
I0035693cellular_componentNOS2-CD74 complex
I0035718molecular_functionmacrophage migration inhibitory factor binding
I0042289molecular_functionMHC class II protein binding
I0042609molecular_functionCD4 receptor binding
I0042613cellular_componentMHC class II protein complex
I0042658molecular_functionMHC class II protein binding, via antigen binding groove
I0042802molecular_functionidentical protein binding
I0043030biological_processregulation of macrophage activation
I0043066biological_processnegative regulation of apoptotic process
I0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
I0043202cellular_componentlysosomal lumen
I0043410biological_processpositive regulation of MAPK cascade
I0043518biological_processnegative regulation of DNA damage response, signal transduction by p53 class mediator
I0044183molecular_functionprotein folding chaperone
I0045058biological_processT cell selection
I0045657biological_processpositive regulation of monocyte differentiation
I0048146biological_processpositive regulation of fibroblast proliferation
I0050998molecular_functionnitric-oxide synthase binding
I0060907biological_processpositive regulation of macrophage cytokine production
I0065003biological_processprotein-containing complex assembly
I0070062cellular_componentextracellular exosome
I0070206biological_processprotein trimerization
I0070374biological_processpositive regulation of ERK1 and ERK2 cascade
I0090023biological_processpositive regulation of neutrophil chemotaxis
I0098553cellular_componentlumenal side of endoplasmic reticulum membrane
I1902166biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
I2000343biological_processpositive regulation of chemokine (C-X-C motif) ligand 2 production
I2000448biological_processpositive regulation of macrophage migration inhibitory factor signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCRVEH
ChainResidueDetails
ATYR161-HIS167
BTYR171-HIS177
site_idPS00484
Number of Residues30
DetailsTHYROGLOBULIN_1_1 Thyroglobulin type-1 repeat signature. FrpkCden.GnYlplQcygsigyc....WCVfpn.G
ChainResidueDetails
CPHE228-GLY257
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues540
DetailsDomain: {"description":"Ig-like C1-type"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues279
DetailsRegion: {"description":"Alpha-2"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues3
DetailsSite: {"description":"Self- and pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"17583734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21115828","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23260142","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4GBX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues6
DetailsSite: {"description":"Self-peptide antigen","evidences":[{"source":"PubMed","id":"31619516","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues3
DetailsSite: {"description":"Self- and pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"21115828","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues3
DetailsSite: {"description":"Self- and pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"17583734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21115828","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31619516","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues3
DetailsSite: {"description":"Pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"23260142","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4GBX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues3
DetailsSite: {"description":"Self- and pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"17583734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21115828","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23260142","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31619516","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4GBX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues3
DetailsSite: {"description":"Pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"17583734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21115828","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23260142","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FQX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GBX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues3
DetailsSite: {"description":"Self- and pathogen-derived peptide antigen","evidences":[{"source":"PubMed","id":"17583734","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23260142","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31619516","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4FQX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GBX","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues6
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7477400","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31619516","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"8145819","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues3
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19303388","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24190431","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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