PDB: 392 件ウェブページステータス検索Chemie searchBIRD

---

6R04	T. cruzi FPPS 分子名称: ACETATE ION, Farnesyl diphosphate synthase, SULFATE ION, ... 著者 Petrick, J.K, Muenzker, L, Schleberger, C, Jahnke, W. 登録日 2019-03-12 公開日 2020-04-01 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery Thesis, 2019
6R08	T. cruzi FPPS in complex with 3-(carboxymethyl)-5,7-dichloro-1H-indole-2-carboxylic acid 分子名称: 3-(carboxymethyl)-5,7-dichloro-1H-indole-2-carboxylic acid, Farnesyl diphosphate synthase, SULFATE ION, ... 著者 Petrick, J.K, Muenzker, L, Schleberger, C, Jahnke, W. 登録日 2019-03-12 公開日 2020-04-01 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.44 Å) 主引用文献 Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery Thesis, 2019
6R06	T. CRUZI FPPS IN COMPLEX WITH (3S,4S)-4-(3,4-dimethylphenoxy)-1-(prop-2-yn-1-yl)piperidin-3-ol 分子名称: (3~{S},4~{S})-4-(3,4-dimethylphenoxy)-1-prop-2-ynyl-piperidin-3-ol, ACETATE ION, Farnesyl diphosphate synthase, ... 著者 Petrick, J.K, Muenzker, L, Schleberger, C, Wolfgang, J. 登録日 2019-03-12 公開日 2020-04-01 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.559 Å) 主引用文献 Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery Thesis, 2019
1YHM	Structure of the complex of Trypanosoma cruzi farnesyl disphosphate synthase with alendronate, Isopentenyl diphosphate and mg+2 分子名称: 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, 4-AMINO-1-HYDROXYBUTANE-1,1-DIYLDIPHOSPHONATE, MAGNESIUM ION, ... 著者 Gabelli, S.B, McLellan, J.S, Montalvetti, A, Oldfield, E, Docampo, R, Amzel, L.M. 登録日 2005-01-09 公開日 2005-12-20 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: Implications for drug design. Proteins, 62, 2005
6R05	T. CRUZI FPPS IN COMPLEX WITH N-BENZYL-6-METHYLPYRIDIN-2-AMINE 分子名称: 6-methyl-~{N}-(phenylmethyl)pyridin-2-amine, ACETATE ION, DIMETHYL SULFOXIDE, ... 著者 Petrick, J.K, Muenzker, L, Schleberger, C, Jahnke, W. 登録日 2019-03-12 公開日 2020-04-01 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery Thesis, 2019
6R07	T. cruzi FPPS in complex with 2-(5-chlorobenzo[b]thiophen-3-yl)acetic acid 分子名称: (5-chloro-1-benzothiophen-3-yl)acetic acid, DIMETHYL SULFOXIDE, Farnesyl diphosphate synthase, ... 著者 Petrick, J.K, Muenzker, L, Schleberger, C, Jahnke, W. 登録日 2019-03-12 公開日 2020-04-01 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery Thesis, 2019
6R09	T. cruzi FPPS in complex with 2-(4-((1H-indol-3-yl)methyl)piperazin-1-yl)benzo[d]thiazole 分子名称: 2-[4-(1~{H}-indol-3-ylmethyl)piperazin-1-yl]-1,3-benzothiazole, Farnesyl diphosphate synthase, SULFATE ION, ... 著者 Petrick, J.K, Muenzker, L, Schleberger, C, Jahnke, W. 登録日 2019-03-12 公開日 2020-04-01 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery Thesis, 2019
6R0A	T. cruzi FPPS in complex with 3-((4-(benzo[d]thiazol-2-yl)piperazin-1-yl)methyl)-1H-indol-5-ol 分子名称: 3-[[4-(1,3-benzothiazol-2-yl)piperazin-1-yl]methyl]-1~{H}-indol-5-ol, ACETATE ION, Farnesyl diphosphate synthase, ... 著者 Petrick, J.K, Muenzker, L, Schleberger, C, Jahnke, W. 登録日 2019-03-12 公開日 2020-04-01 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.32 Å) 主引用文献 Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery Thesis, 2019
6R0B	T. cruzi FPPS in complex with 3-((4-(5-chlorobenzo[d]thiazol-2-yl)piperazin-1-yl)methyl)-1H-indol-5-ol 分子名称: 3-[[4-(5-chloranyl-1,3-benzothiazol-2-yl)piperazin-1-yl]methyl]-1~{H}-indol-5-ol, Farnesyl diphosphate synthase, SULFATE ION, ... 著者 Petrick, J.K, Muenzker, L, Schleberger, C, Jahnke, W. 登録日 2019-03-12 公開日 2020-04-01 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.612 Å) 主引用文献 Targeting farnesyl pyrophosphate synthase of Trypanosoma cruzi by fragment-based lead discovery Thesis, 2019
1YHL	Structure of the complex of Trypanosoma cruzi farnesyl diphosphate synthase with risedronate, dmapp and mg+2 分子名称: 1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE BIS-PHOSPHONIC ACID, DIMETHYLALLYL DIPHOSPHATE, MAGNESIUM ION, ... 著者 Gabelli, S.B, McLellan, J.S, Montalvetti, A, Oldfield, E, Docampo, R, Amzel, L.M. 登録日 2005-01-09 公開日 2005-12-20 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: Implications for drug design. Proteins, 62, 2005
1YHK	Trypanosoma cruzi farnesyl diphosphate synthase 分子名称: SULFATE ION, farnesyl pyrophosphate synthase 著者 Gabelli, S.B, McLellan, J.S, Montalvetti, A, Oldfield, E, Docampo, R, Amzel, L.M. 登録日 2005-01-09 公開日 2005-12-20 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: Implications for drug design. Proteins, 62, 2005
3PKO	Crystal structure of geranylgeranyl pyrophosphate synthase from lactobacillus brevis atcc 367 complexed with citrate 分子名称: CITRIC ACID, GLYCEROL, Geranylgeranyl pyrophosphate synthase 著者 Patskovsky, Y, Toro, R, Rutter, M, Chang, S, Sauder, J.M, Poulter, C.D, Burley, S.K, Gerlt, J.A, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) 登録日 2010-11-11 公開日 2010-11-24 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily. Proc.Natl.Acad.Sci.USA, 110, 2013
3QQV	Crystal structure of geranylgeranyl pyrophosphate synthase from corynebacterium glutamicum complexed with isoprenyl diphosphate and magnesium 分子名称: DIMETHYLALLYL DIPHOSPHATE, GLYCEROL, Geranylgeranyl pyrophosphate synthase, ... 著者 Patskovsky, Y, Toro, R, Sauder, J.M, Poulter, C.D, Gerlt, J.A, Burley, S.K, Almo, S.C, Enzyme Function Initiative (EFI), New York SGX Research Center for Structural Genomics (NYSGXRC) 登録日 2011-02-16 公開日 2011-03-02 最終更新日 2021-02-10 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily. Proc.Natl.Acad.Sci.USA, 110, 2013
3S4J	Human FDPS Synthase in Complex with a Rigid Analog of Risedronate 分子名称: 6,7-dihydro-5H-cyclopenta[b]pyridine-6,6-diylbis(phosphonic acid), Farnesyl pyrophosphate synthase, MAGNESIUM ION, ... 著者 Evdokimov, A.G, Barnett, B.L, Ebetino, F.H, Pokross, M. 登録日 2011-05-19 公開日 2011-06-29 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Human FDPS Synthase in Complex with a Rigid Analog of Risedronate To be Published
3PH7	Crystal structure of Plasmodium vivax putative polyprenyl pyrophosphate synthase in complex with geranylgeranyl diphosphate 分子名称: Farnesyl pyrophosphate synthase, GERANYLGERANYL DIPHOSPHATE 著者 Wernimont, A.K, Dunford, J, Lew, J, Zhao, Y, Kozieradzki, I, Cossar, D, Schapiro, M, Bochkarev, A, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, Hui, R, Artz, J.D, Structural Genomics Consortium (SGC) 登録日 2010-11-03 公開日 2010-11-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites. J.Biol.Chem., 286, 2011
3Q2Q	Crystal structure of geranylgeranyl pyrophosphate synthase from Corynebacterium glutamicum complexed with calcium and isoprenyl diphosphate 分子名称: CALCIUM ION, DIMETHYLALLYL DIPHOSPHATE, GLYCEROL, ... 著者 Patskovsky, Y, Toro, R, Rutter, M, Sauder, J.M, Poulter, C.D, Gerlt, J.A, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) 登録日 2010-12-20 公開日 2011-01-12 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily. Proc.Natl.Acad.Sci.USA, 110, 2013
3RYE	Human FDPS Synthase in Complex with a N-Methyl Pyridinum Bisphosphonate 分子名称: 3-(2-hydroxy-2,2-diphosphonoethyl)-1-methylpyridinium, Farnesyl pyrophosphate synthase, MAGNESIUM ION, ... 著者 Evdokimov, A.G, Barnett, B.L, Ebetino, F.H, Pokross, M. 登録日 2011-05-11 公開日 2011-06-01 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Human FDPS Synthase in Complex with a N-Methyl Pyridinum Bisphosphonate To be Published
3RYW	Crystal structure of P. vivax geranylgeranyl diphosphate synthase complexed with BPH-811 分子名称: Farnesyl pyrophosphate synthase, MAGNESIUM ION, SULFATE ION, ... 著者 No, J.H, Liu, Y.-L, Zhang, Y, Oldfield, E. 登録日 2011-05-11 公開日 2012-05-23 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity. Proc.Natl.Acad.Sci.USA, 109, 2012
3RMG	Crystal structure of geranylgeranyl pyrophosphate synthase from bacteroides thetaiotaomicron 分子名称: Octaprenyl-diphosphate synthase 著者 Patskovsky, Y, Toro, R, Sauder, J.M, Poulter, C.D, Gerlt, J.A, Burley, S.K, Almo, S.C, Enzyme Function Initiative (EFI), New York SGX Research Center for Structural Genomics (NYSGXRC) 登録日 2011-04-20 公開日 2011-05-11 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily. Proc.Natl.Acad.Sci.USA, 110, 2013
3Q1O	Crystal structure of geranyltransferase from helicobacter pylori complexed with magnesium and isoprenyl diphosphate 分子名称: DIMETHYLALLYL DIPHOSPHATE, Geranyltranstransferase (IspA), MAGNESIUM ION, ... 著者 Patskovsky, Y, Toro, R, Rutter, M, Sauder, J.M, Burley, S.K, Poulter, C.D, Gerlt, J.A, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) 登録日 2010-12-17 公開日 2011-01-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily. Proc.Natl.Acad.Sci.USA, 110, 2013
3RBM	Crystal structure of Plasmodium vivax geranylgeranylpyrophosphate synthase complexed with BPH -703 分子名称: 3-(2,2-diphosphonoethyl)-1-dodecyl-1H-imidazol-3-ium, Farnesyl pyrophosphate synthase, MAGNESIUM ION, ... 著者 Liu, Y.L, No, J.H, Oldfield, E. 登録日 2011-03-29 公開日 2012-02-29 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity. Proc.Natl.Acad.Sci.USA, 109, 2012
3TC1	Crystal Structure of Octaprenyl Pyrophosphate Synthase from Helicobacter pylori 分子名称: MAGNESIUM ION, Octaprenyl Pyrophosphate Synthase 著者 Zhang, J.Y, Zhang, X.L, Li, D.F, Zou, Q.M, Wang, D.C. 登録日 2011-08-08 公開日 2011-08-31 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal Structure of Octaprenyl Pyrophosphate Synthase from Helicobacter pylori To be Published
3QKC	CRYSTAL STRUCTURE OF geranyl diphosphate synthase small subunit from Antirrhinum majus 分子名称: Geranyl diphosphate synthase small subunit 著者 Malashkevich, V.N, Toro, R, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) 登録日 2011-01-31 公開日 2011-02-16 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystal structure of geranyl diphosphate synthase small subunit from Antirrhinum majus To be Published
4PVX	Crystal structure of human FPPS in complex with [({4-[4-(cyclopropyloxy)phenyl]pyridin-2-yl}amino)methanediyl]bis(phosphonic acid) 分子名称: Farnesyl pyrophosphate synthase, GLYCEROL, MAGNESIUM ION, ... 著者 Rodionov, D, Park, J, Lin, Y.-S, Tsantrizos, Y.S, Berghuis, A.M. 登録日 2014-03-18 公開日 2015-04-15 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.18 Å) 主引用文献 Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase. PLoS ONE, 12, 2017
4PVY	Crystal structure of human FPPS in complex with [({5-[4-(propan-2-yloxy)phenyl]pyridin-3-yl}amino)methanediyl]bis(phosphonic acid) 分子名称: Farnesyl pyrophosphate synthase, GLYCEROL, MAGNESIUM ION, ... 著者 Rodionov, D, Park, J, De Schutter, J.W, Tsantrizos, Y.S, Berghuis, A.M. 登録日 2014-03-18 公開日 2015-04-15 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Crystallographic and thermodynamic characterization of phenylaminopyridine bisphosphonates binding to human farnesyl pyrophosphate synthase. PLoS ONE, 12, 2017

<12345678910111213141516>