2F8Z

Crystal structure of human FPPS in complex with zoledronate and isopentenyl diphosphate

Summary for 2F8Z

Related2F7M 2F89 2F8C 2F92 2F94 2F9K
DescriptorFarnesyl Diphosphate Synthase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ... (5 entities in total)
Functional Keywordsmevalonate pathway; isoprene biosynthesis; cholesterol biosynthesis; bisphosphonate inhibitor, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P14324
Total number of polymer chains1
Total molecular weight40774.95
Authors
Rondeau, J.-M.,Bitsch, F.,Bourgier, E.,Geiser, M.,Hemmig, R.,Kroemer, M.,Lehmann, S.,Ramage, P.,Rieffel, S.,Strauss, A.,Green, J.R.,Jahnke, W. (deposition date: 2005-12-02, release date: 2006-02-28, Last modification date: 2017-10-18)
Primary citation
Rondeau, J.M.,Bitsch, F.,Bourgier, E.,Geiser, M.,Hemmig, R.,Kroemer, M.,Lehmann, S.,Ramage, P.,Rieffel, S.,Strauss, A.,Green, J.R.,Jahnke, W.
Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs.
Chemmedchem, 1:267-273, 2006
PubMed: 16892359 (PDB entries with the same primary citation)
DOI: 10.1002/cmdc.200500059
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.259190.3%5.7%0.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution