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2F9K

Crystal structure of human FPPS in complex with Zoledronate and Zn2+

Summary for 2F9K
Entry DOI10.2210/pdb2f9k/pdb
Related2F7M 2F89 2F8C 2F8Z 2F92 2F94
DescriptorFarnesyl Diphosphate Synthase, ZINC ION, PHOSPHATE ION, ... (5 entities in total)
Functional Keywordsmevalonate pathway; isoprene biosynthesis; cholesterol biosynthesis; bisphosphonate inhibitor, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P14324
Total number of polymer chains1
Total formula weight40747.14
Authors
Rondeau, J.-M.,Bitsch, F.,Bourgier, E.,Geiser, M.,Hemmig, R.,Kroemer, M.,Lehmann, S.,Ramage, P.,Rieffel, S.,Strauss, A.,Green, J.R.,Jahnke, W. (deposition date: 2005-12-06, release date: 2006-02-28, Last modification date: 2024-02-14)
Primary citationRondeau, J.M.,Bitsch, F.,Bourgier, E.,Geiser, M.,Hemmig, R.,Kroemer, M.,Lehmann, S.,Ramage, P.,Rieffel, S.,Strauss, A.,Green, J.R.,Jahnke, W.
Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs.
Chemmedchem, 1:267-273, 2006
Cited by
PubMed: 16892359
DOI: 10.1002/cmdc.200500059
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.06 Å)
Structure validation

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