2F8Z
Crystal structure of human FPPS in complex with zoledronate and isopentenyl diphosphate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (F) | Farnesyl Diphosphate Synthase | polymer | 350 | 40183.9 | 1 | UniProt (P14324) Pfam (PF00348) | Homo sapiens (human) | FPP synthetase; FPS; Farnesyl pyrophosphate synthetase |
| 2 | B, C, D (F) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 3 | E (F) | 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE | non-polymer | 246.1 | 1 | Chemie (IPE) | |||
| 4 | F (F) | ZOLEDRONIC ACID | non-polymer | 272.1 | 1 | Chemie (ZOL) | |||
| 5 | G (F) | water | water | 18.0 | 61 | Chemie (HOH) |
Sequence modifications
F: 6 - 353 (UniProt: P14324)
| PDB | External Database | Details |
|---|---|---|
| Gly 4 | - | cloning artifact |
| Pro 5 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40183.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 591.1 | |
| All* | Total formula weight | 40775.0 |
