2F94
Crystal structure of human FPPS in complex with ibandronate
Summary for 2F94
Entry DOI | 10.2210/pdb2f94/pdb |
Related | 2F7M 2F89 2F8C 2F8Z 2F92 2F9K |
Descriptor | Farnesyl Diphosphate Synthase, ZINC ION, PHOSPHATE ION, ... (5 entities in total) |
Functional Keywords | mevalonate pathway; isoprene biosynthesis; cholesterol biosynthesis; bisphosphonate inhibitor, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P14324 |
Total number of polymer chains | 1 |
Total formula weight | 40794.28 |
Authors | Rondeau, J.-M.,Bitsch, F.,Bourgier, E.,Geiser, M.,Hemmig, R.,Kroemer, M.,Lehmann, S.,Ramage, P.,Rieffel, S.,Strauss, A.,Green, J.R.,Jahnke, W. (deposition date: 2005-12-05, release date: 2006-02-28, Last modification date: 2024-02-14) |
Primary citation | Rondeau, J.M.,Bitsch, F.,Bourgier, E.,Geiser, M.,Hemmig, R.,Kroemer, M.,Lehmann, S.,Ramage, P.,Rieffel, S.,Strauss, A.,Green, J.R.,Jahnke, W. Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs. Chemmedchem, 1:267-273, 2006 Cited by PubMed: 16892359DOI: 10.1002/cmdc.200500059 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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