2F89

Crystal structure of human FPPS in complex with pamidronate

Summary for 2F89

Related2F7M 2F8C 2F8Z 2F92 2F94 2F9K
DescriptorFarnesyl Diphosphate Synthase, PHOSPHATE ION, MANGANESE (II) ION, ... (5 entities in total)
Functional Keywordsmevalonate pathway; isoprene biosynthesis; cholesterol biosynthesis; bisphosphonate inhibitor, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P14324
Total number of polymer chains1
Total molecular weight40678.71
Authors
Rondeau, J.-M.,Bitsch, F.,Bourgier, E.,Geiser, M.,Hemmig, R.,Kroemer, M.,Lehmann, S.,Ramage, P.,Rieffel, S.,Strauss, A.,Green, J.R.,Jahnke, W. (deposition date: 2005-12-02, release date: 2006-02-28, Last modification date: 2017-10-18)
Primary citation
Rondeau, J.M.,Bitsch, F.,Bourgier, E.,Geiser, M.,Hemmig, R.,Kroemer, M.,Lehmann, S.,Ramage, P.,Rieffel, S.,Strauss, A.,Green, J.R.,Jahnke, W.
Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs.
Chemmedchem, 1:267-273, 2006
PubMed: 16892359 (PDB entries with the same primary citation)
DOI: 10.1002/cmdc.200500059
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2531204.0%1.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution