2F89
Crystal structure of human FPPS in complex with pamidronate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (F) | Farnesyl Diphosphate Synthase | polymer | 350 | 40183.9 | 1 | UniProt (P14324) Pfam (PF00348) | Homo sapiens (human) | FPP synthetase; FPS; Farnesyl pyrophosphate synthetase |
| 2 | B (F) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 3 | C, D, E (F) | MANGANESE (II) ION | non-polymer | 54.9 | 3 | Chemie (MN) | |||
| 4 | F (F) | PAMIDRONATE | non-polymer | 235.1 | 1 | Chemie (210) | |||
| 5 | G (F) | water | water | 18.0 | 55 | Chemie (HOH) |
Sequence modifications
F: 6 - 353 (UniProt: P14324)
| PDB | External Database | Details |
|---|---|---|
| Gly 4 | - | cloning artifact |
| Pro 5 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 40183.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 494.9 | |
| All* | Total formula weight | 40678.7 |
