7KCV
| |
7K8L
| Beta-lactamase, Unmixed | 分子名称: | Beta-lactamase, PHOSPHATE ION | 著者 | Pandey, S, Schmidt, M. | 登録日 | 2020-09-27 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.8000102 Å) | 主引用文献 | Observation of substrate diffusion and ligand binding in enzyme crystals using high-repetition-rate mix-and-inject serial crystallography Iucrj, 8, 2021
|
|
7K8K
| Beta-lactamase mixed with Sulbactam, 60ms | 分子名称: | Beta-lactamase, PHOSPHATE ION, SULBACTAM, ... | 著者 | Pandey, S, Schmidt, M. | 登録日 | 2020-09-27 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Observation of substrate diffusion and ligand binding in enzyme crystals using high-repetition-rate mix-and-inject serial crystallography Iucrj, 8, 2021
|
|
7K8H
| Beta-lactamase mixed with Ceftriaxone, 50ms | 分子名称: | Beta-lactamase, Ceftriaxone, PHOSPHATE ION | 著者 | Pandey, S, Schmidt, M. | 登録日 | 2020-09-27 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.60006261 Å) | 主引用文献 | Observation of substrate diffusion and ligand binding in enzyme crystals using high-repetition-rate mix-and-inject serial crystallography Iucrj, 8, 2021
|
|
7K8F
| Beta-lactamase mixed with Ceftriaxone, 10ms | 分子名称: | Beta-lactamase, Ceftriaxone, PHOSPHATE ION | 著者 | Pandey, S, Schmidt, M. | 登録日 | 2020-09-26 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.60003138 Å) | 主引用文献 | Observation of substrate diffusion and ligand binding in enzyme crystals using high-repetition-rate mix-and-inject serial crystallography Iucrj, 8, 2021
|
|
7K8E
| Beta-lactamase mixed with Ceftriaxone, 5ms | 分子名称: | Beta-lactamase, Ceftriaxone, PHOSPHATE ION | 著者 | Pandey, S, Schmidt, M. | 登録日 | 2020-09-26 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.40005636 Å) | 主引用文献 | Observation of substrate diffusion and ligand binding in enzyme crystals using high-repetition-rate mix-and-inject serial crystallography Iucrj, 8, 2021
|
|
7K2Y
| Crystal structure of CTX-M-14 E166A/K234R Beta-lactamase in complex with hydrolyzed ampicillin | 分子名称: | (2R,4S)-2-[(1R)-1-{[(2R)-2-amino-2-phenylacetyl]amino}-2-oxoethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Beta-lactamase | 著者 | Lu, S, Palzkill, T, Sankaran, B, Hu, L, Soeung, V, Prasad, B.V.V. | 登録日 | 2020-09-09 | 公開日 | 2020-11-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | A drug-resistant beta-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency. J.Biol.Chem., 295, 2020
|
|
7K2X
| Crystal structure of CTX-M-14 E166A/K234R Beta-lactamase | 分子名称: | Beta-lactamase, GLYCEROL | 著者 | Lu, S, Palzkill, T, Sankaran, B, Hu, L, Soeung, V, Prasad, B.V.V. | 登録日 | 2020-09-09 | 公開日 | 2020-11-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A drug-resistant beta-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency. J.Biol.Chem., 295, 2020
|
|
7K2W
| Crystal structure of CTX-M-14 E166A/K234R Beta-lactamase in complex with hydrolyzed cefotaxime | 分子名称: | Beta-lactamase, CEFOTAXIME, C3' cleaved, ... | 著者 | Lu, S, Palzkill, T, Sankaran, B, Hu, L, Soeung, V, Prasad, B.V.V. | 登録日 | 2020-09-09 | 公開日 | 2020-11-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | A drug-resistant beta-lactamase variant changes the conformation of its active-site proton shuttle to alter substrate specificity and inhibitor potency. J.Biol.Chem., 295, 2020
|
|
7E9A
| Crystal structure of KPC-2 in complex with (S)-2-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-3-yl)acrylic acid (4a-(S)) | 分子名称: | 2-[(3S)-1-oxidanyl-3H-2,1-benzoxaborol-3-yl]prop-2-enoic acid, ACETIC ACID, Beta-lactamase, ... | 著者 | Li, G.-B, Yan, Y.-H. | 登録日 | 2021-03-03 | 公開日 | 2021-08-04 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Design and enantioselective synthesis of 3-( alpha-acrylic acid) benzoxaboroles to combat carbapenemase resistance. Chem.Commun.(Camb.), 57, 2021
|
|
7DOO
| |
7DDM
| Crystal Structure of PenA39 beta-Lactamase | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ALA-ALA-ARG-ASP-ALA-ALA-VAL-SER-ASP-ALA-ALA-ALA, ... | 著者 | Nukaga, M, Hoshino, T, Papp-Wallace, K.M. | 登録日 | 2020-10-29 | 公開日 | 2021-11-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Frameshift mutations in genes encoding PBP3 and PBP4 trigger an unusual, extreme beta-lactam resistance phenotype in Burkholderia multivorans To Be Published
|
|
7D5J
| |
7CIN
| |
7BH7
| Room temperature, serial X-ray structure of the ertapenem-derived acylenzyme of CTX-M-15 (10 min soak) collected on fixed target chips at Diamond Light Source I24 | 分子名称: | (2~{S},3~{R},4~{R})-3-[5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl-4-methyl-5-[(2~{S},3~{R})-3-oxidanyl-1-oxidanylidene-butan-2-yl]-3,4-dihydro-2~{H}-pyrrole-2-carboxylic acid, Beta-lactamase, CHLORIDE ION, ... | 著者 | Hinchliffe, P, Tooke, C.L, Butryn, A, Spencer, J. | 登録日 | 2021-01-10 | 公開日 | 2021-07-21 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography. Nat Commun, 12, 2021
|
|
7BH6
| Room temperature, serial X-ray structure of CTX-M-15 collected on fixed target chips at Diamond Light Source I24 | 分子名称: | Beta-lactamase, CHLORIDE ION, SODIUM ION, ... | 著者 | Hinchliffe, P, Tooke, C.L, Butryn, A, Spencer, J. | 登録日 | 2021-01-10 | 公開日 | 2021-07-21 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography. Nat Commun, 12, 2021
|
|
7BH5
| XFEL structure of the ertapenem-derived CTX-M-15 acylenzyme after mixing for 2 sec using a piezoelectric injector (PolyPico) | 分子名称: | (2~{S},3~{R},4~{R})-3-[5-[(3-carboxyphenyl)carbamoyl]pyrrolidin-3-yl]sulfanyl-4-methyl-5-[(2~{S},3~{R})-3-oxidanyl-1-oxidanylidene-butan-2-yl]-3,4-dihydro-2~{H}-pyrrole-2-carboxylic acid, Beta-lactamase, CHLORIDE ION, ... | 著者 | Hinchliffe, P, Tooke, C.L, Butryn, A, Spencer, J. | 登録日 | 2021-01-10 | 公開日 | 2021-07-21 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography. Nat Commun, 12, 2021
|
|
7BH4
| XFEL structure of apo CTX-M-15 after mixing for 0.7 sec with ertapenem using a piezoelectric injector (PolyPico) | 分子名称: | Beta-lactamase, SULFATE ION | 著者 | Hinchliffe, P, Tooke, C.L, Butryn, A, Spencer, J. | 登録日 | 2021-01-10 | 公開日 | 2021-07-21 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography. Nat Commun, 12, 2021
|
|
7BH3
| XFEL structure of CTX-M-15 resting state | 分子名称: | Beta-lactamase, CHLORIDE ION, SULFATE ION | 著者 | Hinchliffe, P, Tooke, C.L, Butryn, A, Spencer, J. | 登録日 | 2021-01-10 | 公開日 | 2021-07-21 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography. Nat Commun, 12, 2021
|
|
7ATL
| EstCE1, a hydrolase with promiscuous acyltransferase activity | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Esterase, ... | 著者 | Palm, G.J, Lammers, M, Berndt, L. | 登録日 | 2020-10-30 | 公開日 | 2020-11-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.478 Å) | 主引用文献 | Discovery and Design of Family VIII Carboxylesterases as Highly Efficient Acyltransferases. Angew.Chem.Int.Ed.Engl., 60, 2021
|
|
7A74
| Structure of G132N BlaC from Mycobacterium tuberculosis | 分子名称: | 1,2-ETHANEDIOL, Beta-lactamase, GLYCEROL, ... | 著者 | Chikunova, A, Ahmad, M.U, Perrakis, A, Ubbink, M. | 登録日 | 2020-08-27 | 公開日 | 2021-05-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Two beta-Lactamase Variants with Reduced Clavulanic Acid Inhibition Display Different Millisecond Dynamics. Antimicrob.Agents Chemother., 65, 2021
|
|
7A72
| Structure of G132S BlaC from Mycobacterium tuberculosis bound to the trans-enamine adduct of sulbactam | 分子名称: | ACETATE ION, Beta-lactamase, GLYCEROL, ... | 著者 | Chikunova, A, Ahmad, M.U, Perrakis, A, Ubbink, M. | 登録日 | 2020-08-27 | 公開日 | 2021-07-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | The G132S Mutation Enhances the Resistance of Mycobacterium tuberculosis beta-Lactamase against Sulbactam. Biochemistry, 60, 2021
|
|
7A71
| Structure of G132S BlaC from Mycobacterium tuberculosis | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Beta-lactamase, GLYCEROL, ... | 著者 | Chikunova, A, Ahmad, M.U, Perrakis, A, Ubbink, M. | 登録日 | 2020-08-27 | 公開日 | 2021-07-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | The G132S Mutation Enhances the Resistance of Mycobacterium tuberculosis beta-Lactamase against Sulbactam. Biochemistry, 60, 2021
|
|
7A6Z
| Structure of P226G BlaC from Mycobacterium tuberculosis | 分子名称: | 1,2-ETHANEDIOL, Beta-lactamase, GLYCEROL, ... | 著者 | Chikunova, A, Ahmad, M.U, Perrakis, A, Ubbink, M. | 登録日 | 2020-08-27 | 公開日 | 2021-10-06 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Conserved proline residues prevent dimerization and aggregation in the beta-lactamase BlaC. Protein Sci., 33, 2024
|
|
7A61
| Crystal structure of KPC-2 with hydrolyzed faropenem (ring-open form) | 分子名称: | (2~{R})-2-[(2~{S},3~{R})-1,3-bis(oxidanyl)-1-oxidanylidene-butan-2-yl]-5-butyl-2,3-dihydro-1,3-thiazole-4-carboxylic acid, Carbapenem-hydrolyzing beta-lactamase KPC, GLYCEROL, ... | 著者 | Tooke, C.L, Hinchliffe, P, Spencer, J. | 登録日 | 2020-08-24 | 公開日 | 2021-02-24 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Faropenem reacts with serine and metallo-beta-lactamases to give multiple products. Eur.J.Med.Chem., 215, 2021
|
|