7Q11
Crystal structure of CTX-M-14 in complex with Ixazomib
Summary for 7Q11
Entry DOI | 10.2210/pdb7q11/pdb |
Related | 7Q0Y 7Q0Z |
Descriptor | Beta-lactamase, DIMETHYL SULFOXIDE, [(1~{R})-1-[2-[[2,5-bis(chloranyl)phenyl]carbonylamino]ethanoylamino]-3-methyl-butyl]boronic acid, ... (6 entities in total) |
Functional Keywords | lactamase, antibiotic, resistence, hydrolase |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 29173.76 |
Authors | Werner, N.,Perbandt, M.,Hinrichs, W.,Prester, A.,Rohde, H.,Aepfelbacher, M.,Betzel, C. (deposition date: 2021-10-17, release date: 2022-04-13, Last modification date: 2024-01-31) |
Primary citation | Perbandt, M.,Werner, N.,Prester, A.,Rohde, H.,Aepfelbacher, M.,Hinrichs, W.,Betzel, C. Structural basis to repurpose boron-based proteasome inhibitors Bortezomib and Ixazomib as beta-lactamase inhibitors. Sci Rep, 12:5510-5510, 2022 Cited by PubMed: 35365689DOI: 10.1038/s41598-022-09392-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.14 Å) |
Structure validation
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