2HNZ
 
 | | Crystal Structure of E138K Mutant HIV-1 Reverse Transcriptase in Complex with PETT-2 | | 分子名称: | 1-[2-(4-ETHOXY-3-FLUOROPYRIDIN-2-YL)ETHYL]-3-(5-METHYLPYRIDIN-2-YL)THIOUREA, PHOSPHATE ION, Reverse transcriptase/ribonuclease H | | 著者 | Ren, J, Nichols, C.E, Stamp, A, Chamberlain, P.P, Stammers, D.K. | | 登録日 | 2006-07-13 | | 公開日 | 2006-09-05 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural insights into mechanisms of non-nucleoside drug resistance for HIV-1 reverse transcriptases mutated at codons 101 or 138.
Febs J., 273, 2006
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1NDV
 | | Crystal Structure of Adenosine Deaminase complexed with FR117016 | | 分子名称: | Adenosine deaminase, N''-(4-(5-((1H-BENZIMIDAZOL-2-YLAMINO)METHYL)-2-THIENYL)-1,3-THIAZOL-2-YL)GUANIDINE, ZINC ION | | 著者 | Kinoshita, T. | | 登録日 | 2002-12-09 | | 公開日 | 2003-12-09 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization
J.Am.Chem.Soc., 126, 2004
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1NDY
 | | Crystal Structure of Adenosine Deaminase Complexed with FR230513 | | 分子名称: | 1-((1R)-1-(HYDROXYMETHYL)-3-(1-NAPHTHYL)PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine Deaminase, ZINC ION | | 著者 | Kinoshita, T. | | 登録日 | 2002-12-09 | | 公開日 | 2003-12-09 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization
J.Am.Chem.Soc., 126, 2004
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1NDW
 | | Crystal Structure of Adenosine Deaminase Complexed with FR221647 | | 分子名称: | 1-((1R)-1-(HYDROXYMETHYL)-3-PHENYLPROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine Deaminase, ZINC ION | | 著者 | Kinoshita, T. | | 登録日 | 2002-12-09 | | 公開日 | 2003-12-09 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization
J.Am.Chem.Soc., 126, 2004
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1NDZ
 | | Crystal Structure of Adenosine Deaminase Complexed with FR235999 | | 分子名称: | 1-((1R)-1-(HYDROXYMETHYL)-3-(6-((3-(1-METHYL-1H-BENZIMIDAZOL-2-YL)PROPANOYL)AMINO)-1H-INDOL-1-YL)PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine Deaminase, ZINC ION | | 著者 | Kinoshita, T. | | 登録日 | 2002-12-09 | | 公開日 | 2003-12-09 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization
J.Am.Chem.Soc., 126, 2004
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2FQX
 | | PnrA from Treponema pallidum complexed with guanosine | | 分子名称: | GUANOSINE, Membrane lipoprotein tmpC | | 著者 | Brautigam, C.A, Deka, R.K, Tomchick, D.R, Machius, M, Norgard, M.V. | | 登録日 | 2006-01-18 | | 公開日 | 2006-02-14 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | The PnrA (Tp0319; TmpC) lipoprotein represents a new family of bacterial purine nucleoside receptor encoded within an ATP-binding cassette (ABC)-like operon in Treponema pallidum
J.Biol.Chem., 281, 2006
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8R7N
 | | Overall structure of the U11 snRNP | | 分子名称: | Programmed cell death protein 7, Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, ... | | 著者 | Zhao, J, Galej, W.P. | | 登録日 | 2023-11-26 | | 公開日 | 2025-02-05 | | 最終更新日 | 2025-02-19 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural basis of 5' splice site recognition by the minor spliceosome.
Mol.Cell, 85, 2025
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4L51
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4L5J
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1L9K
 | | dengue methyltransferase | | 分子名称: | RNA-DIRECTED RNA POLYMERASE, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION | | 著者 | Egloff, M.P, Benarroch, D, Selisko, B, Romette, J.L, Canard, B. | | 登録日 | 2002-03-25 | | 公開日 | 2003-03-25 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | An RNA cap (nucleoside-2'-O-) methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization
Embo J., 21, 2002
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1O5R
 | | Crystal structure of adenosine deaminase complexed with a potent inhibitor | | 分子名称: | 1-[(1R)-3-(6-{[(BENZYLAMINO)CARBONYL]AMINO}-1H-INDOL-1-YL)-1-(HYDROXYMETHYL)PROPYL]-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine deaminase, ZINC ION | | 著者 | Kinoshita, T. | | 登録日 | 2003-10-05 | | 公開日 | 2004-09-21 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors
J.Med.Chem., 47, 2004
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1QXL
 | | Crystal structure of Adenosine deaminase complexed with FR235380 | | 分子名称: | 1-((1R)-1-(HYDROXYMETHYL)-3-{6-[(5-PHENYLPENTANOYL)AMINO]-1H-INDOL-1-YL}PROPYL)-1H-IMIDAZOLE-4-CARBOXAMIDE, Adenosine deaminase, ZINC ION | | 著者 | Kinoshita, T. | | 登録日 | 2003-09-08 | | 公開日 | 2004-09-21 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors
J.Med.Chem., 47, 2004
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1TV6
 | | HIV-1 Reverse Transcriptase Complexed with CP-94,707 | | 分子名称: | 3-[4-(2-METHYL-IMIDAZO[4,5-C]PYRIDIN-1-YL)BENZYL]-3H-BENZOTHIAZOL-2-ONE, reverse transcriptase p51 subunit, reverse transcriptase p66 subunit | | 著者 | Pata, J.D, Stirtan, W.G, Goldstein, S.W, Steitz, T.A. | | 登録日 | 2004-06-28 | | 公開日 | 2004-07-20 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant RTs resistant to other non-nucleoside inhibitors
Proc.Natl.Acad.Sci.USA, 101, 2004
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2P1D
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1JLQ
 | | CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH 739W94 | | 分子名称: | 2-AMINO-6-(3,5-DIMETHYLPHENYL)SULFONYLBENZONITRILE, HIV-1 RT, A-CHAIN, ... | | 著者 | Ren, J, Stuart, D.I, Stammers, D.K. | | 登録日 | 2001-07-16 | | 公開日 | 2001-08-22 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | 2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1.
J.Med.Chem., 44, 2001
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3LSJ
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3LSR
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3LSP
 | | Crystal Structure of DesT bound to desCB promoter and oleoyl-CoA | | 分子名称: | DNA (5'-D(*TP*CP*AP*AP*TP*CP*GP*AP*GP*TP*CP*AP*AP*CP*AP*AP*GP*CP*GP*TP*TP*CP*AP*CP*TP*GP*AP*TP*GP*TP*A)-3'), DNA (5'-D(*TP*TP*AP*CP*AP*TP*CP*AP*GP*TP*GP*AP*AP*CP*GP*CP*TP*TP*GP*TP*TP*GP*AP*CP*TP*CP*GP*AP*TP*TP*G)-3'), DesT, ... | | 著者 | Miller, D.J, White, S.W. | | 登録日 | 2010-02-12 | | 公開日 | 2010-08-04 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | | 主引用文献 | Structural basis for the transcriptional regulation of membrane lipid homeostasis.
Nat.Struct.Mol.Biol., 17, 2010
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1Q1G
 | | Crystal structure of Plasmodium falciparum PNP with 5'-methylthio-immucillin-H | | 分子名称: | 3,4-DIHYDROXY-2-[(METHYLSULFANYL)METHYL]-5-(4-OXO-4,5-DIHYDRO-3H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)PYRROLIDINIUM, ISOPROPYL ALCOHOL, SULFATE ION, ... | | 著者 | Shi, W, Ting, L.M, Kicska, G.A, Lewandowicz, A, Tyler, P.C, Evans, G.B, Furneaux, R.H, Kim, K, Almo, S.C, Schramm, V.L. | | 登録日 | 2003-07-19 | | 公開日 | 2004-03-16 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Plasmodium falciparum Purine Nucleoside Phosphorylase: CRYSTAL STRUCTURES, IMMUCILLIN INHIBITORS, AND DUAL CATALYTIC FUNCTION.
J.Biol.Chem., 279, 2004
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2E1W
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9GD2
 | | Structure of Chd1 bound to a dinucleosome with a dyad-to-dyad distance of 103 bp. | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Chromo domain-containing protein 1, ... | | 著者 | Engeholm, M, Roske, J.J, Oberbeckmann, E, Dienemann, C, Lidschreiber, M, Cramer, P, Farnung, L. | | 登録日 | 2024-08-04 | | 公開日 | 2024-09-18 | | 最終更新日 | 2024-10-02 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Resolution of transcription-induced hexasome-nucleosome complexes by Chd1 and FACT.
Mol.Cell, 84, 2024
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2JLE
 | | Novel indazole nnrtis created using molecular template hybridization based on crystallographic overlays | | 分子名称: | 5-[(5-fluoro-3-methyl-1H-indazol-4-yl)oxy]benzene-1,3-dicarbonitrile, REVERSE TRANSCRIPTASE/RNASEH | | 著者 | Jones, L.H, Allan, G, Barba, O, Burt, C, Corbau, R, Dupont, T, Irving, S, Mowbray, C.E, Phillips, C, Swain, N.A, Webster, R, Westby, M. | | 登録日 | 2008-09-08 | | 公開日 | 2009-08-04 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Novel Indazole Non-Nucleoside Reverse Transcriptase Inhibitors Using Molecular Hybridization Based on Crystallographic Overlays.
J.Med.Chem., 52, 2009
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7EVO
 | | The cryo-EM structure of the human 17S U2 snRNP | | 分子名称: | HIV Tat-specific factor 1, PHD finger-like domain-containing protein 5A, RNA helicase, ... | | 著者 | Zhang, X, Zhan, X, Shi, Y. | | 登録日 | 2021-05-21 | | 公開日 | 2022-08-03 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Structural insights into branch site proofreading by human spliceosome.
Nat.Struct.Mol.Biol., 2024
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6R92
 | | Cryo-EM structure of NCP-THF2(+1)-UV-DDB class B | | 分子名称: | DNA damage-binding protein 1,DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ... | | 著者 | Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H. | | 登録日 | 2019-04-02 | | 公開日 | 2019-06-12 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | DNA damage detection in nucleosomes involves DNA register shifting.
Nature, 571, 2019
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6R90
 | | Cryo-EM structure of NCP-THF2(+1)-UV-DDB class A | | 分子名称: | DNA damage-binding protein 1, DNA damage-binding protein 2, Histone H2A type 1-B/E, ... | | 著者 | Matsumoto, S, Cavadini, S, Bunker, R.D, Thoma, N.H. | | 登録日 | 2019-04-02 | | 公開日 | 2019-06-12 | | 最終更新日 | 2024-05-22 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | DNA damage detection in nucleosomes involves DNA register shifting.
Nature, 571, 2019
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