1NDV
Crystal Structure of Adenosine Deaminase complexed with FR117016
Summary for 1NDV
Entry DOI | 10.2210/pdb1ndv/pdb |
Related | 1NDW 1NDY 1NDZ |
Descriptor | Adenosine deaminase, ZINC ION, N''-(4-(5-((1H-BENZIMIDAZOL-2-YLAMINO)METHYL)-2-THIENYL)-1,3-THIAZOL-2-YL)GUANIDINE, ... (4 entities in total) |
Functional Keywords | structure-based drug design, beta barrel, inhibitor-induced conformational change, hydrolase |
Biological source | Bos taurus (cattle) |
Cellular location | Cell membrane; Peripheral membrane protein; Extracellular side (By similarity): P56658 |
Total number of polymer chains | 1 |
Total formula weight | 40776.55 |
Authors | Kinoshita, T. (deposition date: 2002-12-09, release date: 2003-12-09, Last modification date: 2024-03-13) |
Primary citation | Terasaka, T.,Kinoshita, T.,Kuno, M.,Nakanishi, I. A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization J.Am.Chem.Soc., 126:34-35, 2004 Cited by PubMed: 14709046DOI: 10.1021/ja038606l PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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